National Institute of Pharmaceutical Education and Research
Dept. of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India NIPER HYDERABAD

CONTACT INFORMATION


Dr. Nalini Shastri
Associate Professor
Department of Pharmaceutics
NIPER-Hyderabad

BIOGRAPHY

I have completed B.Pharm, MPharm and PhD from Bombay College of Pharmacy, Mumbai, with Pharmaceutics specialization. I am a certified six sigma green belt with a post graduate diploma in statistical quality control. I also hold a post graduate diploma in Computer programming, system analysis and design. I have worked in various pharmaceutical companies like E.Merck Ltd, Meyer Organics Ltd, Pfimex Pharmaceuticals Ltd, Armour Pharmaceuticals Ltd and Natco Pharma at Managerial level for 8 years. I was an approved chemist in chemical and instrumental analysis by Maharashtra and AP FDA. I later moved to academics and served as HOD and I/C principal at Sri Venkatestwara College of Pharmacy, Hyderabad for 11 years before joining NIPER as an Associate Professor in Oct 2009. I have served as a subject expert in Board of Studies, OU. I am also associated as a member for different IEC for BA/BE studies. I have established a Solid State Pharmaceutical Group (SSPRG) which focuses on solid state formulations, crystal engineering, cocrystals and polymorphs. .

AWARDS  &  QUALIFICATIONS
  • Ph.D in Pharmaceutical Sciences from Bombay University in 1992.
  • M.Pharm in Pharmaceutical Sciences from Bombay University in 1988.
  • B.Pharm from Bombay University in 1986.
  • PG Diploma in Computer programming, System Analysis and Design, Bombay, 1987
  • PG Diploma in Statistical Quality Control, Hyderabad
  • Certified Green belt six sigma, SQC, Hyderabad
  • Qualified GATE in 1986 with 96 percentile (all India 21st rank)


RESEARCH SUMMARY

My research activities in industry include development of different types of IR dosage forms, coated formulations, analytical method development, scale-up, validation and technology transfer. During my industrial tenure, I have launched 3 new products and 2 line extension products in Indian and South African market. I have hands on experience in validation activities right from building construction stage to dosage form processing and have executed IQ, OQ and PQ of various industrial equipments.
My group is currently involved in research area related to solid state pharmaceutics, mesoporous drug delivery systems, Fast dissolving technology, novel oral modified release particulate systems for pediatrics and geriatrics. I take keen interest in use of various software tools for formulation development and crystal/polymorph designing. One of our thrust areas is use of QbD and statistical applications for process and product optimization. Our group contribution has resulted in many national and international awards. I have guided 3 PhD students and 31 Master students, coguided 25 Master students, published 48 papers, 7 invited international book chapters and co-authored a text book on Instrumental Analysis for Dr.Ambedkar OU, AP. I have also filed 1 patent. My two clinical trials have been successfully completed and registered at CTRI.

SOURCE OF FUNDING
  • Department of Pharmaceuticals (DOP), Ministry of chemical & fertilizers, Govt. of India


 

 


PUBLICATIONS
  • Rajesh Thipparaboina, Dinesh Kumar, Rahul B. Chavan and Nalini R. Shastri. Multidrug co-crystals: towards the development of effective therapeutic hybrids. Drug Discov Today 2016, 21, 481–490 (IF=5.625)
  • Supriya Dattatray Jitkar, Rajesh Thipparaboina, Rahul B Chavan, and Nalini R. Shastri, Spherical Agglomeration of Platy Crystals: Curious Case of Etodolac. (2016), Cryst. Growth Des., 2016, 16, 4034–4042 (IF=4.425)
  • Amitha Thakur, Rajesh Thipparaboina, Dinesh Kumar, Kodukula Sai Gouthami, Nalini R Shastri, Crystal Engineered Albendazole with Improved Dissolution and Material Attributes, CrystEngComm, 2016, 18, 1489-1494 (IF=3.849)
  • Rajesh Kumar Gurram, Suchithra Gandra, Nalini R Shastri, Design and optimization of disintegrating pellets of MCC by non-aqueous extrusion process using statistical tools, Eur J Pharm Sci, 2016, 84, 146–156 (IF=3.773)
  • Dinesh Kumar, Rajesh T, Sameer R Modi, Arvind K Bansal, Nalini R Shastri, Effect of HPMC concentration on crystal habit of nifedipine. CrystEngComm, 2015, 17, 1615-1624. (IF=3.849)
  • Kodukula Sai Gouthami, Dinesh Kumar, Rajesh Thipparaboina, Rahul B. Chavan, Nalini R. Shastri, Can crystal engineering be as beneficial as micronisation and overcome its pitfalls?: A case study with cilostazol. Int J Pharm., 2015, 491, 26-34 (IF=3.99).
  • Dinesh Kumar,RajeshThipparaboina, BojjaSreedhar, Nalini R. Shastri, Role of surface chemistry in crystal morphology and its associated properties, CrystEngComm, 2015, 17, 6646 (IF=3.849)
  • Rajesh Thipparaboina, Dinesh Kumar, Sudhir Mittapalli, Sridhar Balasubramanian, Ashwini Nangia,and Nalini R Shastri, Ionic, Neutral, and Hybrid Acid−Base Crystalline Adducts of Lamotrigine with Improved Pharmaceutical Performance, Cryst. Growth Des.,2015, 15, 5816–5826 (IF=4.425)
  • Rajesh Thipparaboina, Rahul B Chavan, Dinesh Kumar, Srivani Modugula, Nalini R Shastri, Micellar Carriers for the Delivery of Multiple Therapeutic Agents. Colloids and Surfaces B: Biointerfaces 2015, 135, 291–308 (IF=3.902)
  • Kalpana M., Ramakrishna Sistla, and Nalini R Shastri. Modulating drug release profiles by lipid semi solid matrix formulations for BCS class II drug – an in vitro and an in vivo study. Drug Delivery, 2015, 22,418-426 (IF=4.843)
  • Abdul Bari Mohd, Krishna Sanka, Srikanth Bandi, Prakash V Diwan, and Nalini Shastri, Solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of glimepiride: development and antidiabetic activity in albino rabbits. Drug Delivery, 2015, 22, 499-508 (IF=4.843)

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