National Institute of Pharmaceutical Education and Research
Dept. of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India NIPER HYDERABAD

CONTACT INFORMATION


Dr. N. Shankaraiah,
Associate Professor
Principal Coordinator for Swachh Bharat Abhiyan
Department of Medicinal Chemistry
NIPER-Hyderabad
Email : shankar.niperhyd@gov.in / shankarnbs@gmail.com
Citations: Google Scholar

BIOGRAPHY

Dr. N. Shankaraiah was born in 1976, and grew up in Andhra Pradesh, India. He did his B.Sc and M.Sc from Kakatiya University, Warangal. He completed PhD work at CSIR-Indian Institute of Chemical Technology, Hyderabad and obtained his doctorate in 2007 from Kakatiya University. He worked as a postdoctoral fellow at the University of Talca in Chile (2007 to 2008). He visited University of CAMPINAS, Brazil to probe some important reactions with ESI-MS/MS. In 2009, he joined as an Assistant Professor at NIPER-Hyderabad. He received prestigious Young Scientist Award-2010 from Organization of Pharmaceutical Producers of India (OPPI). His primary research interest involves design/synthesis of new chemical entities of anticancer agents in drug discovery by innovative strategies, combinatorial chemistry, and asymmetric synthesis including exploration of new useful methodologies for organic synthesis. He involves in the development of alternative sustainable technologies in pharmaceutical sciences – Green chemistry. He has published about 80 research papers including review articles in reputed international journals. In his research group 65 Students have completed for their 1 year M.S (Pharm) projects, 10 Students are working for their 1 year M.S (Pharm) projects (Guide 4 & 6 Co-guide) and 12 PhD students are working for their Doctoral Research (Guide 7 & 5 Co-guide). Three students awarded Ph.D.

AWARDS  &  QUALIFICATIONS
  • Post-Doctoral Associate (2007–2008), Organic Chemistry, Talca University, Chile
  • PhD (2002–2007), Organic & Medicinal Chemistry, Kakatiya University & CSIR-IICT, India
  • M.Sc (1998–2000), Kakatiya University, India
  • B.Sc (1993–1996), Kakatiya University, India
  • OPPI Young Scientist Award – 2010 from Organisation of Pharmaceutical Producers of India
  • Research Project Award: “FONDECYT INCIATION PROJECT” (1 million US$), rated 3rd Rank, Chile
  • SRF (2004–2007) in Chemical Sciences, CSIR, India
  • JRF (2002–2004) in Chemical Sciences, CSIR, India
  • Reviewer for many International Journals.
  • Member (CFO) in Pollution Control Board, Telangana State.
  • Associate Fellow of AP & Telangana State Akademi of Sciences - 2014


RESEARCH SUMMARY

The creation of biological knowledge and medicinal applications makes a major contribution to the identification and development of small drug-like molecules in the discovery process. In our laboratory, we are pursuing design and synthesis of new molecules using novel enabling synthetic strategies and development of new anticancer agents. The targets are selected based on the structural information obtained from ligand-protein crystallographic structures, molecular modeling, novel molecular architecture, important biological activity and interesting mechanism of action. Natural products with desired biological activity at nanomolar range are being considered as lead compounds for further development. With regard to asymmetric total synthesis of natural products, we have devised concise new routes to several families of natural products. Our aim is to devise short, high yielding innovative enantioselective synthetic methods that examine interesting aspects of structure and reactivity. We are also exploring new synthetic methodologies including “Online Mechanistic Investigations by ESI-MS/MS” that are useful in both basic and applied pharmaceutical chemistry. Development of alternative sustainable technologies in pharmaceutical sciences is highly desirable in the context of green chemistry. 

SOURCE OF FUNDING
  • Department of Pharmaceuticals (DoP), Ministry of Chemicals & Fertilizers, Govt. of India,
  • SERB, DST, Start-Up Research Grant (Young Scientist)


 

 


PUBLICATIONS
  • Conventional and microwave-assisted synthesis of new 1H-benzimidazole-thiazolidinedione derivatives: A potential anticancer scaffold; Sharma, P.; Reddy, T. S.; Senwar, K. R.; Kumar, N. P.; Bhargava, S. K.; Shankaraiah, N. Eur. J. Med. Chem. 2017, 138, 234–245 (IF: 4.519)
  • Synthesis of 2,3,6,7-tetramethoxyphenanthren-9-amine: An efficient precursor to access new 4-aza-2,3-dihydropyridophenanthrenes as apoptosis inducing agents; Kumar, N. P.; Sharma, P.; Reddy, T. S.; Nekkanti, S.; Shankaraiah, N.; Lalita, G.; Sujanakumari, S.; Bhargava, S. K.; Naidu, V. G. M.; Kamal, A. Eur. J. Med. Chem. 2017, 127, 305–317 (IF: 4.519)
  • Silver(I)-catalysed domino alkyne-annulation/Diels-Alder reaction: a mild synthetic approach to tetrahydrospiro[carbazole-4,3’-indoline] scaffolds; Sharma, P.; Kumar, N. P.; Krishna, N. H.; Prasanna, D.; Shankaraiah, N. Org. Chem. Front., 2016, 3, 1503–1508 (IF: 4.955)
  • Microwave-assisted direct oxidative synthesis of α-ketoamides from aryl methyl ketones and amines by a water soluble Cu(I)-complex; Nekkanti, S.; Veeramani, K.; Kumar, N. P.; Kamal, A.; Shankaraiah, N. Green Chem., 2016, 18, 3439–3447 (IF. 9.125)
  • Silver-Catalyzed Domino Aza-Annulation/Diels-Alder Cyclization of 2-ene-yne Anilines: A Facile One-Pot Access to Carbazole, Dihydrocarbazole and Tetrahydrocarbazole Frameworks; Krishna, N. H.; Saraswati, A. P.; Sathish, M.; Shankaraiah, N.; Kamal, A. Chem. Comm. 2016, 52, 4581–4584 (IF. 6.319)
  • Iron-Mediated Concise One-Pot Synthesis of 3,5-Diarylpyridines from beta-Nitrostyrenes; Sathish, M.; Chetna, J.; Krishna, N. H.; Shankaraiah, N.; Alarifi, A.; Kamal, A. J. Org. Chem. 2016, 81, 2159–2165 (IF. 4.849)
  • TBAI/TBHP-Catalyzed [3+2] cycloaddition / oxidation / aromatization cascade and online ESI-MS mechanistic studies: Synthesis of pyrrolo[2,1-a]isoquinolines and indolizino[8,7-b]indoles; Nekkanti, S.; Kumar, N. P.; Sharma, P.; Kamal, A.; Nachtigall, F. M.; Forero-Doria, O.; Santos, L. S.; Shankaraiah, N. RSC Adv. 2016, 6, 2671–2677 (IF. 3.108)
  • Spirooxindole-derived morpholine-fused-1,2,3-triazoles: Design, synthesis, cytotoxicity and apoptosis inducing studies; Senwar, K. R.; Sharma, P.; Reddy, T. S.; Jeengar, M. K.; Nayak, V. L.; Naidu, V. G. M.; Kamal, A. Shankaraiah, N. Eur. J. Med. Chem. 2015, 102, 413–424 (IF. 4.519)
  • Copper Oxide Nanoparticles Supported on Graphene Oxide-Catalyzed S-Arylation: An Efficient and Ligand-Free Synthesis of Aryl Sulfides; Kamal, A.; Srinivasulu, V.; Murty, J. N. S. R. C.; Shankaraiah, N.; Nagesh, N.; Reddy, T. S.; Rao. A. V. S. Adv. Syn. Cat. 2013, 355, 2297–2307 (IF. 5.646)
  • Water Mediated Heck and Ullmann Couplings by Supported Palladium Nanoparticles: Importance of Surface Polarity of the Carbon Spheres; Kamal, A.; Srinivasulu, V.; Seshadri, B. N.; Markandeya, N.; Alarifi, A.; Shankaraiah. N. Green Chem., 2012, 14, 2513–2522 (IF. 9.125)
  • A One-pot Azido Reductive Tandem Mono-N-Alkylation Employing Dialkylboron Triflates: Online ESI-MS Mechanistic Investigation; Shankaraiah, N.; Markandeya, N.; Srinivasulu, V.; Sreekanth, K.; Reddy, Ch. S.; Santos, L. S.; Kamal, A. J. Org. Chem. 2011, 76, 7017–7026 (IF. 4.849)

View More information >>

National Institute of Pharmaceutical Education and Research (NIPER) | Balanagar | Hyderabad - 500037 | India | (+91) 040 23073741 / 40 | Fax: (+91) 040 23073751
Copyright © 2016 NIPER Hyderabad - Designed & Maintained by Computer Centre