National Institute of Pharmaceutical Education and Research
Dept. of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India NIPER HYDERABAD

CONTACT INFORMATION


Dr Ashutosh Kumar,
Assistant Professor,
Department of Pharmacology & Toxicology,
NIPER-Hyderabad

BIOGRAPHY

I studied pharmaceutical sciences at College of pharmacy, Delhi University. After that I joined NIPER Mohali for pursuing MS Pharm from Department of pharmacology and Toxicology, NIPER mohali. I entered neuropharmacology research and worked in same specialization for my doctoral degree which I completed in the year 2011. I worked in various capacities in big pharmaceutical companies like Novartis healthcare private limited and Dr Reddys laboratories before joining NIPER Hyderabad as assistant professor. Currently I am associated with department of pharmacology and toxicology, NIPER Hyderabad and continuing my academic research in the area of diabetic neuropathy and neuropathic pain.

AWARDS  &  QUALIFICATIONS
  • B Pharm: DIPSAR formerly known as Delhi college of Pharmacy, delhi university (2000-2004)
  • MS Pharm: National Institute of Pharmaceutical Education and Research, Mohali (2004-2006)
  • PhD: National Institute of Pharmaceutical Education and Research, Mohali (2006-2011)
  • DST fast track young scientist
  • PC Dandiya Gold medal at IPS 2007


RESEARCH SUMMARY

I am working in the diabetic neuropathy and peripheral neuropathies for past 8 years looking at the pathophysiology underlying peripheral nerve disorder. Our research is motivated by the vision of understanding interlinked mechanisms contributing towards the neuronal damage in diabetic condition and under nerve injury due to trauma or chemotherapy exposure. Most of the research done in this area has been focused on symptomatically relieving neuropathy outcomes. But the research on mechanistic approach towards treatment regimen is albeit very less. We tried to explore few of pathomechanisms like oxidative nitrosative stress, PARP over-activation, advanced glycation end product formation, MAPK activation and activation of transcription factors like Nuclear kappa B. The research work accomplished so far has been published in many of reputed journals and has been widely cited by scientific community

SOURCE OF FUNDING
  • Department of Pharmaceuticals (DOP), Ministry of chemical & fertilizers, Govt. of India
  • Department of Science and Technology , Govt of India.
  • Department of Biotechnology, Govt of India.


 

 


PUBLICATIONS
  • Aparna Areti, Yerra Veera Ganesh, VGM Naidu, Ashutosh Kumar Oxidative stress and Nerve Damage: Role in Chemotherapy Induced Peripheral Neuropathy Redox Biology, 2014, 2, 289-295)
  • S Sandireddy, Yerra Veera Ganesh, Aparna Areti, Prasanth Komirishetti, Ashutosh Kumar Neuroinflammation and Oxidative Stress in Diabetic Neuropathy: Futuristic Strategies Based on these Targets. International Journal of Endocrinology, Special issue entitled “Oxidative Stress and Inflammation in Diabetic Complications”. 2014)
  • Ajit Vikram, Durga Nand Tripathi, Ashutosh Kumar, Sandeep Singh “Oxidative stress and Inflammation in Diabetic Complications” International Journal of Endocrinology. 2014)
  • Dinesh Thummuri, Manish Kumar Jeengar, Shweta Shrivastava, Aparna Areti, Veera Ganesh Yerra, Samyuktha Yamjala, Prashanth Komirishetty, V.G.M. Naidu, Ashutosh Kumar, Ramakrishna Sistla Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in Triple Negative Breast Cancer cells. Environmental Toxicology and Pharmacology 2014, 38( )1, 58–70. )
  • Manish Kumar Jeengar, Shweta Shrivastava, Veera Ganesh Yerra, VGM Naidu, Ramakrishna Sistla, Ashutosh Kumar Curcumin: A Pleiotropic Phytonutrient in Diabetic Complications Nutrition 2014 (in press) )
  • Ashutosh Kumar, Manish Kumar Jeengar , VGM Naidu ; Sugar sweet: the bitter truth. Nutrition (In Press)
  • YV Ganesh, G Negi, SS Sharma, A Kumar, (2013) Potential therapeutic effects of targeting Nrf2-NF-kB pathways in diabetic neuropathy. Redox Biology 1, 394-397.
  • Kumar A, Negi G, Sharma, SS, Neuroprotection by Resveratrol in Diabetic Neuropathy: Concepts and Mechanism. (in press Current Medicinal Chemistry, 2013)
  • Joshi RK, Negi G, Kumar A, Pawar Y, Bansal AK, Sharma SS. (2013) SNEDDS curcumin formulation attenuates pain and functional deficits associated with diabetic neuropathy: An insight into mechanism of neuroprotection. Nanomedicine: Nanotechnology, Biology and Medicine 9 (6), 776-785.
  • Kumar A, Negi G, Sharma, SS. (2012) Suppression of NF-κB and NF-κB regulated oxidative stress and neuroinflammation by BAY 11-7082 (IκB phosphorylation inhibitor) in experimental diabetic neuropathy. Biochimie 94 (5), 1158-1165.
  •  Kumar A, Negi G, Sharma SS. (2011) JSH-23 targets nuclear factor-kappa B and reverses various deficits in experimental diabetic neuropathy: effect on neuroinflammation and antioxidant defence. Diab Obes Metab 13 (8), 750-758

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