National Institute of Pharmaceutical Education and Research
Dept. of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India NIPER HYDERABAD

CONTACT INFORMATION


Dr. N. Satheesh Kumar,
Assistant Professor,
Department of Pharmaceutical Analysis
NIPER-Hyderabad
http://satheshrx.wix.com/satheesh

BIOGRAPHY

He has been with NIPER Hyderabad since 2010. He has completed his PhD (Pharmacy) from Jadavpur University, Kolkata, India. His research is focused on method development for drug analysis includes determination of drug metabolites in different biological matrices, transport mechanisms, evaluation of metabolic stability, assessment of enzyme inhibition and induction. Another area of interest to him is research in pharmacological screening of various natural product isolates and standardization of herbal medicine using hyphenated analytical techniques (LC/MS, LC). His research is supported by Govt. agencies. For his great scientific achievement, he received (1) Start-Up Research Grant (Young Scientists) by DST, Government of India; (2) awarded IDMA Young Pharmaceutical Analyst Award-2014 for his outstanding contributions in the area of Pharmaceutical Analysis; (3) recipient of IDMA-Best Paper in Pharmaceutical Analysis Discipline in year 2015. He is also a reviewer for the Journal of Pharmaceutical and Biomedical Analysis (Elsevier Science), Journal of Ethnopharmacology (Elsevier Science).

AWARDS  &  QUALIFICATIONS
  • PhD (Pharmacy), Jadavpur University, Kolkata, India [2010]
  • M. Pharm (Pharmaceutical Analysis) [2006]
  • B. Pharm [2004]
  • IDMA-Best Paper in Pharmaceutical Analysis Discipline in year 2015
  • DST -International Travel Support (Young Scientist) to France -2015
  • Indian Drug Manufacturers' Association (IDMA)- Young Pharmaceutical Analyst Award -2014
  • DST- Start up research grants scheme for Young Scientists -2013
  • DST -International Travel Support (Young Scientist) to Brazil -2008
  • Awarded as a Senior Research Fellow funded by Dabur Research Foundation (DRF), India (2006-2007).
  • Research Fellow from the University Grant Commission [UGC], Govt of India
  • Best Paper Award, Indian Journal of Pharmaceutical Education & Research -2008
  • Life Member- Association of Pharmaceutical Teachers of India [TL/TLM - 068]


RESEARCH SUMMARY

My research area of interest is primarily associated with fields of Pharmaceutical Analysis. In the area of analysis I am focusing on drug stability, metabolism, pharmacokinetics and drug transporters. My lab is working on identifying the role of CYP enzymes in toxicity induced by drugs, herbal remedies. I am also actively performing application of analytical tools in evaluation of quality and safety of herbal products (DDI & HDI), fingerprinting and standardization of marker compounds in medicinal plant products, separation and characterization (LC-MS/GC-MS) of compounds obtained from synthetic/plant extracts and their possible therapeutic use. In the field of pharmacology and nanomedicine, I am keenly interested in developing a suitable dosage form for the delivery of phytoceuticals for the treatment of various life style disorders.
  • Drug-drug interactions (CYP450 inhibition and induction)
  • In Vitro metabolic stability using liver S9 fraction, microsomes and hepatocytes
  • In vitro Methods for Studying Hepatic Drug Transport and Transporter-Mediated Inhibition
  • Forced degradation studies


SOURCE OF FUNDING
  • Department of Pharmaceuticals (DOP), Ministry of chemical & fertilizers, Govt. of India
  •  DST, Start-Up Research Grant (Young Scientists)
  •  Council of Scientific & Industrial Research [CSIR]


 

 


PUBLICATIONS
  • A validated LC-ESI-MS/MS method for estimation of glimepiride and pitavastatin in rat plasma: Application to drug interaction studies. Shruti Surendran, David Paul, Ratna Sushmita, Lavanya Krishna, Nirbhay Kumar Tiwari, Sanjeev Giri, Nanjappan Satheeshkumar. Journal of Chromatography B. (Accepted); 2017 (IF: 2.68)
  • Isolation, characterization using LC-ESI-QTOF, NMR and in vitro cytotoxicity assay of Niclosamide forced degradation products. Johnsirani P.,Vishnuvardhan Ch., Lingesh A, Naidu V.G.M., Naveen Ch., Satheeshkumar N. Journal of Pharmaceutical and Biomedical Analysis (2017); http://dx.doi.org/10.1016/j.jpba.2017.01.001 (IF: 3.16)
  • LC-ESI-MS/MS evaluation of forced degradation behaviour of silodosin: In vitro anti cancer activity evaluation of silodosin and major degradation products. Vishnuvardhan C, Saibaba B, Allakonda L, Swain D, Gananadhamu S, Srinivas R, Satheeshkumar N. J Pharm Biomed Anal. 2017; 134:1-10. doi: 10.1016/j.jpba.2016.11.013 (IF: 3.16)
  • Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones. Dhanabal Kumarasamy, Biswajit Gopal Roy, Joana Rocha-Pereira, Johan Neyts, Satheeshkumar Nanjappan, Subhasis Maity, Musfiqua Mookerjee, Lieve Naesens. Bioorganic & Medicinal Chemistry Letters 27 (2017) 139–142. (IF: 2.48)
  • In vivo metabolic investigation of silodosin using UHPLC–QTOF–MS/MS and in silico toxicological screening of its metabolites. Chiguru Vishnuvardhan, Saibaba Baikadi, Roshan M Borkar, R. Srinivas, N. Satheeshkumar. Journal of Mass Spectrometry, 2016; 51 (10): 677-692. (IF: 2.54)
  • Forced degradation study of racecadotril: Effect of co-solvent, characterization of degradation products by UHPLC-Q-TOF-MS/MS, NMR and cytotoxicity assay. Vishnuvardhan Ch, Allakonda L, Srinivas R, Satheeshkumar N. Journal of Pharmaceutical and Biomedical Analysis 128 (2016) 9–17 (IF: 3.16)
  • Study of forced degradation behaviour of brinzolamide using LC-ESI- Q-TOF and in silico toxicity prediction. Chiguru Vishnuvardhan, Debasish Swain, Roshan Borkar, S. Gananadhamu, R. Srinivas, N. Satheeshkumar. Chromatographia 2016, 79: 1293. doi:10.1007/s10337-016-3149-2 (IF: 1.33)
  • Pharmacokinetic and protein binding profile of peptidomimetic DPP-4 inhibitor – Teneligliptin in rats using liquid chromatography–tandem mass spectrometry. S. Shantikumar, N. Satheeshkumar, R. Srinivas. Journal of Chromatography B, 1002 (2015) 194–200 (IF: 2.68)
  • A sensitive and selective liquid chromatography mass spectrometry method for simultaneous estimation of anti-diabetic drugs inhibiting DPP-4 enzyme in human plasma. Overcoming challenges associated with low recovery and sensitivity. Shanti Kumar S, Satheeshkumar N, Prasanth B, Lingesh A, Paul D, Srinivas R. Anal. Methods, 2015, 7, 6198-6206 (IF: 1.91)

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