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Faculty Profile : Dr. Amol G. Dikundwar

Name: Dr. Amol G. Dikundwar


Assistant Professor
amol.dikundwar@niperhyd.ac.in
+91 40 23074750 Extn- 2035
+91-040-23074750 (Ext. No: 2036)
Citations Link
BRIEF PROFILE

Dr. Amol G. Dikundwar is an analytical scientist with expertise in materials characterization and pharmaceutical analysis. He earned his PhD in Chemical Sciences from the Indian Institute of Science (IISc), Bengaluru, in 2013, and brings over seven years of industrial experience in materials science engineering and analytical R&D. He has contributed to multidisciplinary drug discovery and development programmes, including process analytical technologies (PAT) and regulatory support for drug substances and drug products.

Since February 2021, Dr. Amol has been at NIPER Hyderabad, where he leads an interdisciplinary research group focused on understanding how molecular structure, solid-state properties, formulation design, and biological interactions collectively influence drug performance, quality, and therapeutic outcomes. His laboratory integrates crystallography, crystal engineering, advanced solid-state pharmaceutics, and modern analytical and bioanalytical approaches to address challenges across the pharmaceutical development continuum.



ADDRESS, ROOM NO

Department of Pharmaceutical Analysis
Room no: 05
NIPER Hyderabad
Balanagar, Hyderabad-500037, TS, INDIA



QUALIFICATION: (REVERSE CHRONOLOGICAL ORDER)

Doctor of Philosophy (Ph.D.)

Institute: Solid state and Structural Chemistry Unit, Indian Institute of Science, Bangalore, India [2008-2013]
Dissertation: Organic Flourine in Crystal engineering: Consequences at Molecular and Supramolecular level. (Thesis advisor: Professor T. N. Guru Row; worked with Prof. G. R. Desiraju on collaborative projects)
Research areas: In situ cryocrystallography, crystal engineering and polymorphism, charge density analysis, neutron diffraction, powder diffraction

Master of Science (M.Sc.)

Institute: Department of Chemistry, RTM Nagpur University, Nagpur, India [2005-2007] (First division)
Specialization: Organic chemistry with Medicinal chemistry as optional credits

Bachelor of Science (B.Sc.)

Institute: Lokmanya Tilak Mahavidyalaya, Wani, SGB Amaravati University, Amaravati, India [2002-2005] (Distinction)
Specialization: Major Subjects: Physics, Chemistry and Mathematics


EXPERIENCE

  • Assistant Professor, January 2021 - Till date at NIPER, Hyderabad, India

  • Principal Investigator (Apr 2018 - Jan 2021) at Analytical Research & Development, Biocon Bristol-Myers Squibb Research and Development Center, Syngene International Limited, Bangalore, India
    Role: Leading solid state characterization, small molecule crystallography and IR/Raman PAT teams, Matrix leader for Material Selection and Development Team, Member of extended leadership team in the organization

  • Senior Research Investigator (Jan 2016 - Mar 2018) at Analytical Research & Development, Biocon Bristol-Myers Squibb Research and Development Center, Syngene International Limited, Bangalore, India
    Role: Team leader for solid state characterization and small molecule crystallography team

  • Research Investigator (Sep 2013 - Dec 2015) at Biopharmaceutics, Biocon Bristol-Myers Squibb Research and Development Center, Syngene International Limited, Bangalore, India
    Role: Crystallography support to discovery and development projects



COURSES HANDLING(PHD/M.PHARM)

  • PA 510: Topics in Pharmaceutical Analysis
  • GE 511: Seminar
  • LG 510: General Lab Experience
  • PA 620: Modern Instrumental Techniques for Evaluation of APIs and Drug Products
  • PE 660: Solid State Pharmaceutics
  • RA 611: Drug Substance and Drug Product Development (Partial)
  • MC 630: Structure and Function of Biomolecules (Partial)
  • GE 611: Seminar
  • LS 610: General Lab Experience
  • PA 740: Liquid Chromatography in Pharmaceutical Analysis
  • PA 710: Impurity and Metabolite Profiling
  • PA 750: Analytical Chemometrics
  • MD 117: Pharmacopeial Methods of Analysis



PHD STUDENTS/MASTERS STUDENTS
Current students
PhD students
Sr. No.Name
1Rekha Sapkal
2Shiva Gogikar
3Siddhartha Nagamalli
4Ramakanta Patel
5Avvaru Jubha Jahnavi
6P. Shivashankar
7Sibu Sen
8Shraddha Katarpawar
9Rushikesh Suradkar
10Abhishek Sharma (under co-supervision)
Masters students
Sr. No.Name
1Chandrakanta Mohapatra
2Irkar Vaishanvi Maddappa
3Jagtap Yash Machindra
4Guru Naik
5Pappu Sarkar
6Waghmare Mahesh Namdev
Alumni
PhD students
Sr. No.Name
1Nagesh Bhale
Masters students
Sr. No.Name
1Pratik Pramod Deshpande
2Pratima Kendre
3Pallavi Jock
4Quadri Syeda Sadaf
5Shaikh Nadeem Nazeemsab
6Sibu Sen
7Yerukala Penugonda Raghvendra
8Agade Suraj Bhaskar
9Birajdar Ganesh Pandit
10Daravath Sandeep
11Gobade Ganesh Pandurang
12Kamuni Vinathi
13Vartika Ranjit Singh
14Sodnar Ashok Mhatu
15Srishti Singh
16G. Jyothi
17Pawan M. Kurhade
18Soumyajit Dey
19Onkar Sarjerao Solanke
20Faizan Toufeeque Momin
21Munesh Kumari
22Sasitharan N
23Vedang Junagade
24Pravin Vikaram Chavan
25Ganashree G
26Ramadevi S
27Tejas Dhon
28Vishal Maurya

AWARDS / HONOURS
  • Poster prize at Applied Pharmaceutical Analysis conference (APA-India 2020) at Ahmedabad, India
  • “BMS Bravo Award-2018” for establishing PoC of using existing small molecule crystallography set up for protein data collection
  • “Excellence Award-2018” for successful in-house transition of a molecule across various stages of drug development
  • First position (team Soch) in case study analysis and presentation competition on “Diversity and Inclusion”, 2017
  • “Galaxy Award-2016” for successful completion of lead optimization for Allied Bristol-Myers Squibb Life Sciences (ABLS-02) program
  • “BMS Star Award-2015” for organising and conducting a short course (20 hours) ‘Polymorphism and Crystallization in Pharmaceuticals’ for fellow scientists within PD organization
  • “CCDC Poster Prize” in the 22nd IUCr general assembly, Madrid, Spain for the presentation of the poster entitled “‘Organic’ Fluorine Dictates the Molecular Conformation and Packing” in August 2011
  • “IUCr Best Poster Award” in the ICCOSSXX, Bangalore, India for the presentation of the poster entitled “Structural Variability in the Monofluorophenylacetylenes Mediated through Interactions Involving ‘Organic’ Fluorine” in June 2011
  • Qualified National Eligibility Test (NET-2007, JRF) and Graduate Aptitude Test Examination (GATE-2008, percentile 98.88)
  • National Cadet Corps (NCC) A, B and C certificates
  • Member of Indian Crystallography Association and Marathi Vidhyan Parishad, Mumbai
  • Member of International Center for Diffraction Data (ICDD)


RESEARCH AREAS/INTEREST
Pharmaceutical Materials Science and Engineering

The laboratory focuses on the rational design, development, and characterization of pharmaceutical solid forms to improve the physicochemical and biopharmaceutical performance of drug molecules. Research encompasses form screening and selection of polymorphs, salts, cocrystals, eutectics, hydrates, solvates, neat amorphous forms, coamorphous systems, and amorphous solid dispersions. The group investigates solid-state phase transformations, relative polymorphic stability, polyamorphism, crystallisation pathways and process development, and formulation enablement strategies to support pharmaceutical development while mitigating solid-form-related risks during manufacturing and commercialization.

Research in crystallography is directed towards understanding molecular and supramolecular organization in pharmaceutical materials using advanced structural characterization techniques. The laboratory employs single-crystal X-ray diffraction for structure elucidation, crystallographic computations, quantum chemical calculations, and experimental and theoretical charge-density analyses to investigate intermolecular interactions and structure-property relationships. Structural information is further utilized to predict physicochemical behaviour, support lead optimization, and understand molecular packing using data from the Cambridge Structural Database.

The laboratory employs a comprehensive suite of analytical techniques to characterize pharmaceutical materials and investigate their solid-state behaviour. Research includes high-resolution powder X-ray diffraction, indexing, profile fitting, Rietveld refinement, ab initio structure determination, and advanced amorphous characterization using total scattering and pair distribution function (TS-PDF) analysis. Complementary techniques such as DSC, mDSC, TGA, DVS, FTIR, Raman spectroscopy, Karl Fischer titration, optical microscopy, and particle size and morphology analysis are routinely applied to establish structure-property relationships and evaluate pharmaceutical performance.

Particle Engineering and Pharmaceutical Process Development

Research focuses on developing robust pharmaceutical processes for producing stable and manufacturable drug substances and dosage forms. Major areas include crystallization process development, particle engineering, particle size optimization, crystal habit modification and morphology control, milling, process optimization, scale-up considerations, and accelerated solid-state stability studies of drug substances, intermediates, and finished pharmaceutical products.

Analytical and Bioanalytical Development

The laboratory is involved in the development and validation of analytical and bioanalytical methods for qualitative and quantitative analysis of pharmaceuticals, complex formulation matrices, biological samples, nutraceuticals, and environmental matrices. Research activities include pharmaceutical impurity profiling, forced degradation studies, stability-indicating analytical methods, trace-level contaminant analysis, and regulatory-compliant analytical method development using HPLC, UHPLC, LC-MS/MS, LC-HRMS, GC-MS, and ICP-MS platforms.

Drug Metabolism, Pharmacokinetics and Translational Pharmaceutical Research

The laboratory investigates the influence of formulation design and molecular properties on drug disposition and therapeutic performance. Research includes pharmacokinetic and pharmacodynamic evaluation, drug metabolism, drug-drug interaction studies, CYP enzyme phenotyping, in vitro-in vivo extrapolation (IVIVE), and physiologically based pharmacokinetic (PBPK) modelling to support rational pharmaceutical development and translational research.

Pharmacometabolomics and Systems Pharmacology

By integrating advanced mass spectrometry with computational data analysis, the group performs targeted and untargeted metabolomics for biomarker discovery, cancer metabolomics, phytometabolomics, and systems-level investigations aimed at elucidating mechanisms of drug action, therapeutic efficacy, and precision pharmacotherapy. Such pharmacometabolomics and systems pharmacology investigations are leveraged for understanding metabolic alterations associated with drug therapy, disease progression, and therapeutic response.

Natural Products, Nutraceuticals and Environmental Pharmaceutical Sciences

The laboratory applies advanced analytical technologies to evaluate the quality, authenticity, and safety of natural products, traditional formulations, nutraceuticals, and environmental samples. Research interests include phytochemical characterization, phyto-metabolomics, network pharmacology, detection of organic and inorganic contaminants in food and nutritional supplements, heavy metal toxicity assessment and trace elemental analysis using ICP-MS, monitoring of pharmaceutical contaminants in environmental matrices, and assessment of their potential impact on human health and environment.



FELLOWSHIPS / GRANTS
  • Awarded Junior Research Fellowship (2008-2010) and Senior Research Fellowship (2010-2013) by Ministry of HRD, Government of India, India
  • Several travel grants for attending international conferences, synchrotron data collection (Elletra, Italy), neutron data collection (ANSTO, Australia).

PUBLICATIONS / BOOK CHAPTERS

  1. Pathak, R. K.; Dikundwar, A. G.; Guru Row, T. N.; Rao, C. P. A Lower Rim Triazole Linked Calix[4]arene Conjugate as a Fluorescence Switch on Sensor for Zn²⁺ in Blood Serum Milieu. Chem. Commun. 2010, 46 (24), 4345–4347.
    https://doi.org/10.1039/C0CC00219D
  2. Zade, C. M.; Pete, U. D.; Dikundwar, A. G.; Bendre, R. S. (Z)-2-(2-Isopropyl-5-methylphenoxy)-N′-(2-Oxoindolin-3-ylidene)acetohydrazide. Acta Crystallogr., Sect. E 2010, 66 (7), o1614.
    https://doi.org/10.1107/S1600536810019008
  3. Thakur, T. S.; Sathishkumar, R.; Dikundwar, A. G.; Guru Row, T. N.; Desiraju, G. R. Third Polymorph of Phenylacetylene. Cryst. Growth Des. 2010, 10 (10), 4246–4249.
    https://doi.org/10.1021/cg101076k
  4. Prasad, K. R.; Chandrakumar, A.; Dikundwar, A. G.; Guru Row, T. N. Polymorphism in a TADDOL Analogue Induced by the Presence of a Chiral Impurity. CrystEngComm 2010, 12, 3452–3454.
    https://doi.org/10.1039/c0ce00103a
  5. Dikundwar, A. G.; Venkateswarlu, C.; Piltz, R. O.; Chandrasekaran, S.; Guru Row, T. N. Crystal Structures of Fluorinated Aryl Biscarbonates and a Biscarbamate: A Counterpoise between Weak Intermolecular Interactions and Molecular Symmetry. CrystEngComm 2011, 13, 1531–1538.
    https://doi.org/10.1039/c0ce00537a
  6. Bandela, A.; Chinta, J. P.; Hinge, V. K.; Dikundwar, A. G.; Row, T. N. G.; Rao, C. P. Recognition of Polycyclic Aromatic Hydrocarbons and Their Derivatives by the 1,3-Dinaphthalimide Conjugate of Calix[4]arene: Emission, Absorption, Crystal Structures, and Computational Studies. J. Org. Chem. 2011, 76, 1742–1750.
    https://doi.org/10.1021/jo1023409
  7. Manjunatha, M. N.; Dikundwar, A. G.; Nagasundara, K. R. Zn(II), Cd(II), and Hg(II) Complexes with 1-(p-Methoxybenzyl)-2-(p-Methoxyphenyl)benzimidazole: Syntheses, Structures, and Luminescence. Polyhedron 2011, 30, 1299–1304.
    https://doi.org/10.1016/j.poly.2011.02.018
  8. Wazalwar, S. S.; Bhave, N. S.; Dikundwar, A. G.; Ali, P. Microwave-Assisted Synthesis and Antimicrobial Study of Schiff Base Vanadium(IV) Complexes of Phenyl Esters of Amino Acids. Synth. React. Inorg., Met.-Org., Nano-Met. Chem. 2011, 41, 459–464.
    https://doi.org/10.1080/15533174.2011.568427
  9. Dikundwar, A. G.; Dutta, G. K.; Guru Row, T. N.; Patil, S. Polymorphism in Opto-Electronic Materials with a Benzothiazole-Fluorene Core: A Consequence of High Conformational Flexibility of π-Conjugated Backbone and Alkyl Side Chains. Cryst. Growth Des. 2011, 11, 1615–1622.
    https://doi.org/10.1021/cg101579f
  10. Sancheti, R. S.; Dikundwar, A. G.; Bendre, R. S. 2-{[{2-Hydroxy-3-[2-Methyl-5-(propan-2-yl)phenoxy]propyl}(pyridin-2-ylmethyl)amino]methyl}phenol. Acta Crystallogr., Sect. E: Struct. Rep. Online 2011, 67 (7), o1605–o1605.
    https://doi.org/10.1107/S1600536811020952
  11. Dikundwar, A. G.; Guru Row, T. N. “Organic” Fluorine Dictates the Molecular Conformation and Packing. Acta Crystallogr., Sect. A 2011, 67, C367.
    https://doi.org/10.1107/S0108767311090751
  12. Pathak, R. K.; Dikundwar, A. G.; Guru Row, T. N.; Rao, C. P. A Lower Rim Triazole Linked Calix[4]arene Conjugate as a Fluorescence Switch on Sensor for Zn²⁺ in Blood Serum Milieu. Chem. Commun. 2010, 46 (24), 4345–4347.
    https://doi.org/10.1039/C0CC00219D
  13. Dikundwar, A. G.; Guru Row, T. N. Evidence for the “Amphoteric” Nature of Fluorine in Halogen Bonds: An Instance of Cl···F Contact. Cryst. Growth Des. 2012, 12 (4), 1713–1716.
    https://doi.org/10.1021/cg3002477
  14. Aitipamula, S.; Banerjee, R.; Bansal, A. K.; Biradha, K.; Cheney, M. L.; Choudhury, A. R.; Desiraju, G. R.; Dikundwar, A. G.; Dubey, R.; Duggirala, N.; Ghogale, P. P.; Ghosh, S.; Goswami, P. K.; Goud, N. R.; Jetti, R. R. K. R.; Karpinski, P.; Kaushik, P.; Kumar, D.; Kumar, V.; Moulton, B.; Mukherjee, A.; Mukherjee, G.; Myerson, A. S.; Puri, V.; Ramanan, A.; Rajamannar, T.; Reddy, C. M.; Rodriguez-Hornedo, N.; Rogers, R. D.; Guru Row, T. N.; Sanphui, P.; Shan, N.; Shete, G.; Singh, A.; Sun, C. C.; Swift, J. A.; Thaimattam, R.; Thakur, T. S.; Thaper, R. K.; Thomas, S. P.; Tothadi, S.; Vangala, V. R.; Variankaval, N.; Vishweshwar, P.; Weyna, D. R.; Zaworotko, M. J. Polymorphs, Salts, and Cocrystals: What’s in a Name? Cryst. Growth Des. 2012, 12 (5), 2147–2152.
    https://doi.org/10.1021/cg3002948
  15. Pete, U. D.; Zade, C. M.; Bhosale, J. D.; Tupe, S. G.; Chaudhary, P. M.; Dikundwar, A. G.; Bendre, R. S. Hybrid Molecules of Carvacrol and Benzoyl Urea/Thiourea with Potential Applications in Agriculture and Medicine. Bioorg. Med. Chem. Lett. 2012, 22 (17), 5550–5554.
    https://doi.org/10.1016/j.bmcl.2012.06.082
  16. Dikundwar, A. G.; Pete, U. D.; Zade, C. M.; Bendre, R. S.; Guru Row, T. N. Tracing a Common “Origin” of Phase Transformation, Polymorphism, Disorder, Isosterism, and Isostructuralism in Fluorobenzoylcarvacryl Thiourea. Cryst. Growth Des. 2012, 12 (9), 4530–4534.
    https://doi.org/10.1021/cg300699r
  17. Shah, S. R.; Navathe, S. S.; Dikundwar, A. G.; Guru Row, T. N.; Vasella, A. Thermal Rearrangement of Azido Ketones into Oxazoles via Azirines: One-Pot, Metal-Free Heteroannulation to Functionalized 1,3-Oxazoles. Eur. J. Org. Chem. 2013, 2013 (2), 264–267.
    https://doi.org/10.1002/ejoc.201201269
  18. Dikundwar, A. G.; Venkateswarlu, C.; Chandrakala, R. N.; Chandrasekaran, S.; Guru Row, T. N. H/F Isosteric Substitution to Attest Different Equi-Energetic Molecular Conformations in Crystals. CrystEngComm 2013, 15 (27), 5403–5406.
    https://doi.org/10.1039/C3CE40697K
  19. Dikundwar, A. G.; Sathishkumar, R.; Guru Row, T. N. Fluorine Prefers Hydrogen Bonds over Halogen Bonds! Insights from Crystal Structures of Some Halofluorobenzenes. Z. Kristallogr. Cryst. Mater. 2014, 229 (9), 609–624.
    https://doi.org/10.1515/zkri-2014-1750
  20. Dikundwar, A. G.; Guru Row, T. N. Tracing a Crystallization Pathway of an RT Liquid, 4-Fluorobenzoyl Chloride: Metastable Polytypic Form as an Intermediate Phase. Cryst. Growth Des. 2014, 14 (9), 4230–4235.
    https://doi.org/10.1021/cg500460n
  21. Pete, U. D.; Dikundwar, A. G.; Sharma, V. M.; Gejji, S. P.; Bendre, R. S.; Guru Row, T. N. Partial Rotation of the Isopropyl Group in the Solid State: Single-Crystal-to-Single-Crystal Phase Transformation in a Carvacrol Derivative. CrystEngComm 2015, 17 (39), 7482–7485.
    https://doi.org/10.1039/C5CE01156F
  22. Dikundwar, A. G.; Chodon, P.; Thomas, S. P.; Bhutani, H. Supramolecular Chemistry of BrettPhos and BrettPhos Oxide: Breakup of Isostructurality via Order–Disorder Phase Transitions. Cryst. Growth Des. 2017, 17 (4), 1982–1990.
    https://doi.org/10.1021/acs.cgd.6b01905
  23. Harikrishnan, L. S.; Warrier, J.; Tebben, A. J.; Tonukunuru, G.; Madduri, S. R.; Baligar, V.; Mannoori, R.; Seshadri, B.; Rahaman, H.; Arunachalam, P. N.; Dikundwar, A. G.; Fink, B. E.; Fargnoli, J.; Fereshteh, M.; Fan, Y.; Lippy, J.; Ho, C.-P.; Wautlet, B.; Sheriff, S.; Ruzanov, M.; Borzilleri, R. M. Heterobicyclic Inhibitors of Transforming Growth Factor Beta Receptor I (TGFβRI). Bioorg. Med. Chem. 2018, 26 (5), 1026–1034.
    https://doi.org/10.1016/j.bmc.2018.01.014
  24. Dikundwar, A. G.; Pal, S.; Chodon, P.; Narasimhamurthy, R.; Kameshwar, P.; Sundaram, M.; Bhutani, H. Solid State Behavior of Impurities during “In-Process” Phase Purity Analysis of an API. Org. Process Res. Dev. 2019, 23 (2), 269–273.
    https://doi.org/10.1021/acs.oprd.8b00334
  25. Sundaram, M.; Natarajan, S.; Dikundwar, A. G.; Bhutani, H. Quantification of Solid-State Impurity with Powder X-Ray Diffraction Using Laboratory Source. Powder Diffr. 2020, 35, 226–232.
    https://doi.org/10.1017/S0885715620000500
  26. Karmakar, A.; Nimje, R. Y.; Silamkoti, A.; Pitchai, M.; Basha, M.; Singarayer, C.; Ramasamy, D.; Babu, G. T.; Samikannu, R.; Subramaniam, S.; Anjanappa, P.; Vetrichelvan, M.; Kumar, H.; Dikundwar, A. G.; Gupta, A.; Gupta, A. K.; Rampulla, R.; Dhar, T. G.; Mathur, A. Practical Synthesis of (3aR, 9bR)-8-Fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole: An Advanced Intermediate to Access the RORγt Inverse Agonist BMT-362265. Org. Process Res. Dev. 2021, 25 (4), 1001–1014.
    https://doi.org/10.1021/acs.oprd.1c00019
  27. Patil, S. S.; Tadavi, S. K.; Dikundwar, A.; Bendre, R. S. The Transition Metal Complexes of Fe(II), Ni(II) and Cu(II) Derived from Phthalazine-Based Ligands: Synthesis, Crystal Structures and Biological Activities. J. Mol. Struct. 2022, 1247, 131293.
    https://doi.org/10.1016/j.molstruc.2021.131293
  28. Ramachandran, R.; Narayanam, M.; Wethman, R.; Jayaraman, K.; Dikundwar, A.; Bhutani, H. Applications of Raman Spectroscopy in Solvent Distillation and Exchange During Early-Phase Chemical Synthesis. Spectroscopy 2022, 37 (5), 28–39.
    https://doi.org/10.56530/spectroscopy.cd1689c2
  29. Thomas, S. P.; Dikundwar, A. G.; Sarkar, S.; Pavan, M. S.; Pal, R.; Hathwar, V. R.; Row, T. N. G. The Relevance of Experimental Charge Density Analysis in Unraveling Noncovalent Interactions in Molecular Crystals. Molecules 2022, 27 (12), 3690.
    https://doi.org/10.3390/molecules27123690
  30. Tamizhmathy, M.; Gupta, U.; Shettiwar, A.; Kumar, G. S.; Daravath, S.; Aalhate, M.; Mahajan, S.; Maji, I.; Sriram, A.; Modak, C.; Rajalakshmi, A. N.; Dikundwar, A. G.; Doijad, N.; Guru, S. K.; Singh, P. K. Formulation of Inclusion Complex of Abiraterone Acetate with 2-Hydroxypropyl-β-Cyclodextrin: Physiochemical Characterization, Molecular Docking and Bioavailability Evaluation. J. Drug Delivery Sci. Technol. 2023, 82, 104321.
    https://doi.org/10.1016/j.jddst.2023.104321
  31. Sudheendranath, A.; Thomas, S. P.; Dikundwar, A. G.; Bhale, N. A. Variable Cl···O Halogen Bonding Modes in Dimorphs of a Room Temperature Liquid Ethyl Chloroformate Revealed by In Situ Cryo-Crystallography. Cryst. Growth Des. 2023, 23 (6), 4301–4312.
    https://doi.org/10.1021/acs.cgd.3c0011
  32. Katta, C.; Shaikh, A. S.; Bhale, N.; Jyothi, V. G. S.; Kaki, V. R.; Dikundwar, A. G.; et al. Naringenin-Capped Silver Nanoparticles Amalgamated Gel for the Treatment of Cutaneous Candidiasis. AAPS PharmSciTech 2023, 24 (5), 126.
    https://doi.org/10.1208/s12249-023-02581-0
  33. Sharma, A.; Katta, C. B.; Bahuguna, D.; Veerabomma, H.; Mourya, A.; Jyothi, V. G. S.; et al. Voriconazole–Syringic Acid Co-Crystals Reduced Voriconazole-Induced Hepatotoxicity: In Vitro and In Vivo Studies. J. Drug Delivery Sci. Technol. 2023, 86, 104685.
    https://doi.org/10.1016/j.jddst.2023.104685
  34. Ateeq, M. A. M., Aalhate, M., Mahajan, S., Kumar, G. S., Sen, S., Singh, H., ... & Singh, P. K. (2023). Self-nanoemulsifying drug delivery system (SNEDDS) of docetaxel and carvacrol synergizes the anticancer activity and enables safer toxicity profile: optimization, and in-vitro, ex-vivo and in-vivo pharmacokinetic evaluation. Drug Delivery and Translational Research, 13(10), 2614-2638.
    https://doi.org/10.1007/s13346-023-01356-1
  35. Ghuge, S.; Rahman, Z.; Bhale, N. A.; Dikundwar, A. G.; Dandekar, M. P. Multistrain Probiotic Rescinds Quinpirole-Induced Obsessive-Compulsive Disorder Phenotypes by Reshaping the Microbiota–Gut–Brain Axis in Rats. Pharmacol. Biochem. Behav. 2023, 232, 173652.
    https://doi.org/10.1016/j.pbb.2023.173652
  36. Ingle, K. S.; Thakur, J. S.; Bhale, N. A.; Dikundwar, A. G.; Nayak, S. K. Mesomorphic and Computational Evaluation of C≡N···I Halogen-Bonded Complexes of 4-Alkoxy-4′-cyanobiphenyl Systems with 1,6-Diiodoperfluorohexane. J. Mol. Struct. 2023, 1291, 135995.
    https://doi.org/10.1016/j.molstruc.2023.135995
  37. Sapkal, R.; Quadri, S.; Mahajan, R.; Padhy, H. P.; Asthana, A.; Samanthula, G.; Dikundwar, A. G. Forced Degradation of an Anticancer Drug Apalutamide: Impurity Profiling and Structure Elucidation Study. Chromatographia 2024, 87 (1), 71–82.
    https://doi.org/10.1007/s10337-023-04294-9
  38. Mahajan, R.; Sharma, A.; Patra, B.; Mani, L.; Grover, P.; Kumar, S.; et al. Investigation on Photo-Isomeric Impurity of Roxadustat: Structure Conformation, Physicochemical Characterization, Interconversion Feasibility and In Vitro Toxicological Evaluation. J. Mol. Struct. 2024, 1298, 137017.
    https://doi.org/10.1016/j.molstruc.2023.137017
  39. Mahajan, R.; Bishnani, A.; Sapkal, R.; Dikundwar, A. G.; Gananadhamu, S.; Asthana, A. Integrative Analysis of Tepotinib Forced Degradation: Combining In Silico and Liquid Chromatography–Quadrupole Time-of-Flight Tandem Mass Spectrometry Approaches for Structural Elucidation. Sep. Sci. Plus 2024, 7 (4), 2300227.
    https://doi.org/10.1002/sscp.202300227
  40. Menon, A. M.; Sidhartha, N. N.; Shruti, I.; Suresh, A.; Meena, R.; Dikundwar, A. G.; Chopra, D. Synthon Approach in Crystal Engineering to Modulate Physicochemical Properties in Organic Salts of Chlorpropamide. Mol. Pharmaceutics 2024, 21 (6), 2894–2907. https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.4c00043
  41. Katta, C. B.; Bahuguna, D.; Veerabomma, H.; Gollapalli, S.; Shaikh, A. S.; Bhale, N. A.; et al. Naringenin–Zinc Oxide Nanocomposites Amalgamated Polymeric Gel Augmented Drug Delivery and Attenuated Experimental Cutaneous Candidiasis in BALB/c Mice: In Vitro and In Vivo Studies. AAPS PharmSciTech 2024, 25 (5), 130.
    https://doi.org/10.1208/s12249-024-02841-7
  42. Rahman, Z.; Bhale, N. A.; Dikundwar, A. G.; Dandekar, M. P. Multistrain Probiotics with Fructooligosaccharides Improve Middle Cerebral Artery Occlusion–Driven Neurological Deficits by Revamping the Microbiota–Gut–Brain Axis. Probiotics Antimicrob. Proteins 2024, 16 (4), 1251–1269.
    https://doi.org/10.1007/s12602-023-10109-y
  43. Sen, S.; Ganta, B.; Rachel, V. N.; Gogikar, S. K.; Singh, V.; Sonti, R.; Dikundwar, A. G. Mapping Advantages and Challenges in Analytical Development for Fixed-Dose Combination Products: A Review. J. Pharm. Sci. 2024, 113 (8), 2028–2043.
    https://doi.org/10.1016/j.xphs.2024.04.025
  44. Mukhopadhyay, N.; Sen, S.; Kumar, A.; Sandbhor, R.; Dikundwar, A. G.; Kaki, V. R. Understanding Molecular Mechanisms behind the Anti-Inflammatory Effects of Machilus macrantha (Gulmavu) by Network Pharmacology and Molecular Modeling Approach. J. Comput. Biophys. Chem. 2025, 24 (8), 985–1007.
    https://doi.org/10.21203/rs.3.rs-5288974/v1
  45. Thakur, J. S.; Dash, O.; Ingle, K. S.; Lahoti, K. B.; Sudheendranath, A.; Bhale, N. A.; et al. Photoresponsive Halogen-Bonded Complexes of 1,3,5-Trifluoro-2,4,6-triiodobenzene and Alkoxyazopyridine Derivatives Based on Py–N···I Interactions: Synthesis, Structural, and Theoretical Insights. Cryst. Growth Des. 2024, 24 (22), 9391–9402. https://pubs.acs.org/doi/10.1021/acs.cgd.4c00781
  46. Bhale, N. A.; Shah, S.; Jahnavi, A. S.; Vishwakarma, A.; Thakur, T. S.; Thomas, S. P.; et al. Three Strikingly Different Crystal Habits of Tadalafil: Design, Characterization, Pharmaceutical Performance, and Computational Studies. Mol. Pharmaceutics 2024, 21 (12), 6234–6244. https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.4c00601
  47. Gogikar, S. K.; Sen, S.; Daravath, S.; Aalhate, M.; Mahajan, S.; Ateeq, M. A. M.; et al. Bioanalytical Method Development and Validation of Docetaxel and Carvacrol in Mice Plasma Using LC-QqQ-MS/MS. Eur. J. Mass Spectrom. 2024, 30 (5–6), 235–245.
    https://doi.org/10.1177/14690667241289
  48. Sharma, A.; Dey, S.; Sidhartha, N. N.; Shah, S.; Sapkal, R.; Srivastava, S.; Dikundwar, A. G. Coamorphous Systems of Rebamipide: Selection of Amino Acid Coformers Based on Protein–Ligand Docking, In Vitro Assessment, and Study of Interactions by Computational and Multivariate Analysis. Int. J. Pharm. 2024, 667, 124955.
    https://doi.org/10.1016/j.ijpharm.2024.124955
  49. Agade, S.; Bhale, N. A.; Pulipati, P.; Shaik, N. M.; Samanthula, G.; Dikundwar, A. G. Simultaneous Quantitative Determination of Five Process-Relevant Impurities in Menatetrenone. Sep. Sci. Plus 2025, 8 (1), e202400244.
    https://doi.org/10.1002/sscp.202400244
  50. Srikanth, D.; Shejul, G. D.; Joshi, S. V.; Kalam, A.; Jahnavi, A. S.; Dikundwar, A. G.; et al. Transition Metal-Free One-Pot Tandem Chemoselective Reduction and Cyclization of 3/5-(2-Nitrophenyl)-1H-pyrazoles Using Sodium Dithionite. Org. Biomol. Chem. 2025, 23 (24), 5812–5820.
    https://doi.org/10.1039/d5ob00610d
  51. Sahoo, D. K.; Nayak, A.; Dannarm, S. R.; Jahnavi, A. S.; Dikundwar, A. G.; Sonti, R.; Gowd, K. H. Pyrimidine Derivative Mimicking the Locked Enol Form of Avobenzone Acts as a Photostable UVAII and UVB Filter. J. Photochem. Photobiol., A 2025, 459, 116099.
    https://doi.org/10.1016/j.jphotochem.2024.116099
  52. Gogikar, S. K.; Sen, S.; Pathinti, S.; Samanthula, G.; Dikundwar, A. G. Forced Degradation Study of an Anti-Diabetic Drug Imeglimin: Impurity Profiling and Structure Elucidation Using LC-Q-ToF-MS/MS and NMR. Rapid Commun. Mass Spectrom. 2025, 39 (5), e9960.
    https://doi.org/10.1002/rcm.9960
  53. Sapkal, R.; Devangan, P.; Madan, J.; Dikundwar, A. G. Neat Amorphous Form and Amorphous Solid Dispersions of Apalutamide: A Comparative Study. J. Drug Delivery Sci. Technol. 2025, 106, 106678.
    https://doi.org/10.1016/j.jddst.2025.106678
  54. Shaikh, A. S.; Kumar, A.; Makhal, P. N.; Ikhe, A. S.; Bhale, N.; Dikundwar, A. G.; Rao Kaki, V. Selective C3 Functionalization of 4H-Pyrido[1,2-a]pyrimidin-4-Ones via Glyoxylic Acid: Tuning Products with Temperature and Solvents. Asian J. Org. Chem. 2025, 14 (5), e202400790.
    https://doi.org/10.1002/ajoc.202400790
  55. Bhale, N. A.; Birajdar, G.; Agade, S.; Khemchandani, R.; Shekhar, C.; Shaik, M.; et al. An Unusual, Methylated Impurity in Diethyl Sulphate: Identification, Structure Elucidation, and Linkage with N-Methyl Impurity of an Active Pharmaceutical Ingredient. ChemistrySelect 2025, 10 (21), e04945.
    https://doi.org/10.1002/slct.202404945
  56. Prajapati, A. K.; Subha Jahnavi, A.; Pradhan, A. K.; Vishwakarma, A.; Rahman, A.; Dikundwar, A. G.; Thomas, S. P. Toward “Crystal De-Engineering”: Stable, Homogeneous Coamorphous Drug–Tannic Acid Systems Exhibiting Modified Dissolution Rates. Cryst. Growth Des. 2025, 25 (13), 5087–5096. https://pubs.acs.org/doi/10.1021/acs.cgd.5c00599
  57. Kumar, P.; Malik, P.; Ali, J.; Saxena, D.; Singampalli, A.; Bandela, R.; Yaddanapudi, V. M. Exploration of Pyrazole-Based Pyridine-4-carbohydrazide Derivatives as Drug-Resistant Mtb Agents: Design, Synthesis, Biological Evaluation, and In Silico Studies. Future Med. Chem. 2025, 17 (12), 1391–1405.
    https://doi.org/10.1080/17568919.2025.2525069
  58. Devabattula, G.; Bakchi, B.; Sharma, A.; Sidhartha, N. N.; Dikundwar, A. G.; Yeddanapudi, V. M.; Godugu, C. Mitochondria-Targeting SIRT3 Activator Effectively Controls Bleomycin-Induced Pulmonary Fibrosis. BioFactors 2025, 51 (4), e70032.
    https://doi.org/10.1002/biof.70032
  59. Kumar, P.; Malik, P.; Ali, J.; Saxena, D.; Singampalli, A.; Rani, B.; et al. Exploration of New Dihydroindazole Derivatives as Promising Anti-TB Agents: Design, Synthesis, In Silico, and Biological Evaluation. Arch. Pharm. 2025, 358 (8), e70074.
    https://doi.org/10.1002/ardp.70074
  60. Sharma, A.; Shah, S.; Wagh, S.; Pandey, G.; Pradhan, A. K.; Shukla, S.; et al. Ever-Increasing Role of Computational Tools in Solid-State Pharmaceutics: Advancing Drug Development with Enhanced Molecular Understanding and Risk Assessment. Mol. Pharmaceutics 2025, 22 (9), 5165–5192. https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c00296
  61. Kumar, P.; Malik, P.; Ali, J.; Saxena, D.; Singampalli, A.; Bandela, R.; et al. Exploration of Pyridine-4-hydrazide Derivatives as Promising Antitubercular Agents: Synthesis, Biological Evaluation, and In Silico Studies. ChemistrySelect 2025, 10 (36), e01301.
    https://doi.org/10.1002/slct.202501301
  62. Prasad, S. B.; Shinde, A.; Srinivasrao, D. A.; Famta, P.; Shah, S.; Kolipaka, T.; et al. Metal-Organic Frameworks as Therapeutic Chameleons: Revolutionizing Cancer Therapy Employing Novel Nanoarchitectonics. Asian J. Pharm. Sci. 2025, 20 (5), 101054.
    https://doi.org/10.1016/j.ajps.2025.101054
  63. Kalam, A.; Tiwari, M.; Pawar, G.; Srikanth, D.; Joshi, S. V.; Bhale, N. A.; et al. Sodium Dithionite-Mediated One-Pot, Tandem Reductive Cyclization of 2-(2-Nitrophenyl)quinazolin-4(3H)-one with Diverse Aldehydes and Glyoxals. Synthesis 2025, 57 (20), 2983–2996.
    https://doi.org/10.1055/a-2655-4585
  64. Mukhopadhyay, N.; Sen, S.; Kumar, A.; Sandbhor, R.; Dikundwar, A. G.; Kaki, V. R. Understanding Molecular Mechanisms behind the Anti-Inflammatory Effects of Machilus macrantha (Gulmavu) by Network Pharmacology and Molecular Modeling Approach. J. Comput. Biophys. Chem. 2025, 24 (8), 985–1007.
    https://doi.org/10.1142/S2737416525500061
  65. Dastari, S.; Kopuri, S.; Jha, A.; Avvaru, S. J.; Dikundwar, A. G.; Shankaraiah, N. Metal-Free, Solvent-Controlled Divergent Synthesis of Substituted α-Keto Amides/Benzimidazoquinazolines: DFT, Crystallographic Analysis, and In Silico Studies. J. Mol. Struct. 2025, 144581.
    https://doi.org/10.1016/j.molstruc.2025.144581
  66. Bhale, N. A.; Subha Jahnavi, A.; Khemchandani, R.; Vambhurkar, G.; Suradkar, R. V.; Shah, S.; et al. Drug–Drug Coamorphous System of Tadalafil and Finasteride for Enhanced Pharmaceutical Performance. Mol. Pharmaceutics 2025, 23 (1), 127–138. https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c00513
  67. Sen, S.; Mukhopadhyay, N.; Singh, S.; Kaki, V. R.; Somabattini, R. A.; Nanjappan, S. K.; Dikundwar, A. G. ‘Dawa-ul-kurkum’, a Potential Anti-Diabesity Polyherbal Formulation: Phyto-Metabolomics, Network Pharmacology, Molecular Docking and Simulation Studies Supported by In Vitro Activity. J. Comput. Biophys. Chem. 2025, 24 (10), 1311–1329.
    https://doi.org/10.1142/S273741652550022X
  68. Mukhopadhyay, N.; Satti, S.; Sen, S.; Kumar, A.; Sandbhor, R.; Dikundwar, A. G.; et al. Exploring the Potential Targets and Elucidating the Molecular Mechanisms Underlying the Anti-Inflammatory Activity of Plectranthus amboinicus (Karpuravalli) in the Arachidonic Acid Metabolic Pathway by Network Pharmacology, Molecular Docking, and Experimental Validation. J. Comput. Biophys. Chem. 2026, 25 (11), 2325–2349.
    https://doi.org/10.1142/S2737416526500122
  69. Kumari, S.; Gogikar, S. K.; Dikundwar, A. G.; Dubey, S. K.; Taliyan, R. Development and Validation of RP-HPLC Method for Simultaneous Determination of Decitabine and Repaglinide: Application to Solid Lipid Nanoparticle Formulations with In Vitro Neurotoxicity Assessment. Chromatographia 2026, 89 (1), 11–24.
    https://doi.org/10.1007/s10337-025-04453-0
  70. Thakur, J. S.; Dash, O.; Bhale, N. A.; Mondal, P. K.; Dikundwar, A. G.; Polentarutti, M.; Nayak, S. K. Structural and Computational Study of Reversibly Photoswitchable (E)-4-((4-Alkoxyphenyl)diazenyl)benzonitrile-Based Liquid Crystals. CrystEngComm 2026, 28 (2), 485–491.
    https://doi.org/10.1039/d5ce00980d
  71. Sidhartha, N. N.; Dey, S.; Chilvery, S.; Sharma, A.; Godugu, C.; Dikundwar, A. G. Coamorphous System of Tamoxifen and Curcumin: Tailored Release, Synergism, and Enhanced Pharmacological Outcomes to Combat Breast Cancer. J. Drug Delivery Sci. Technol. 2026, 108076.
    https://doi.org/10.1016/j.jddst.2026.108076
  72. Thakur, J. S.; Dash, O.; Bhale, N. A.; Mondal, P. K.; Dikundwar, A. G.; Nayak, S. K. Structural, Thermal, and Computational Investigation into Halogen-Bonded Photoresponsive Alkoxy Azo Benzonitrile Derivatives. Cryst. Growth Des. 2026. https://pubs.acs.org/doi/10.1021/acs.cgd.5c01450
  73. Veerabomma, H.; Bhattacharjee, S.; Goud, K. S.; Kumar, J.; Chandanapalli, D. K.; Bhale, N. A.; Madan, J. Tofacitinib Citrate Nanoemulgel Induced Repigmentation in Vitiligo: Assessment of Oxidative Stress, Protein, Immunohistochemistry, and mRNA Expressions. Int. J. Pharm. 2026, Article 126719.
    https://doi.org/10.1016/j.ijpharm.2026.126719
  74. Singitham, S.; Galla, M. S.; Avvaru, S. J.; Sathish, M.; Kumari, P.; Dikundwar, A. G.; Shankaraiah, N. Visible-Light Mediated One-Pot Synthesis of Pyrazolo[3,4-b]Pyridines via Intramolecular Rearrangement. Asian J. Org. Chem. 2026, 15 (3), e70344.
    https://doi.org/10.1002/ajoc.70344
  75. Patel, R.; Nallathambi, S.; Talari, K.; Bhale, N. A.; Dikundwar, A. G. Potentially Toxic Metals Contamination in Dietary Supplements: Implications on Human Exposure and Health Risk Assessment. Next Res. 2026, 101613.
    https://doi.org/10.1016/j.nexres.2026.101613
  76. Mukhopadhyay, N.; Satti, S.; Sen, S.; Kumar, A.; Sandbhor, R.; Dikundwar, A. G.; Dandekar, M. P. Elucidation of Potential Anti-Inflammatory Targets of Machilus macrantha (Gulmavu) by Utilizing GC–MS, Network Pharmacological Analysis, and Experimental Validation. J. Pharm. Innov. 2026, 21 (2), 173.
    https://doi.org/10.1007/s12247-026-10389-1
  77. Joshi, S. V.; Patil, S.; Srikanth, D.; Shaikh, A. S.; Kalam, A.; Tamang, N.; Nanduri, S. Molecular Iodine-Enabled Cascade Oxidation and Annulation for the Construction of Polycyclic 5-Aroyl-5,6-dihydropyrazolo[1,5-c]quinazolines. Asian J. Org. Chem. 2026, 15 (4), e70389.
    https://doi.org/10.1002/ajoc.70389
  78. Khemchandani, R.; Pardhi, E.; Jadhav, A.; Shaikh, N.; Bhale, N.; Pilli, P.; Samanthula, G. Mechanistic Enhancement of Oral Bioavailability through Coamorphous Apremilast–Aceclofenac Systems: Integrated LC–MS/MS Bioanalysis, In Vivo Pharmacokinetics, and PBPK Modeling. Eur. J. Pharm. Biopharm. 2026, 115099.
    https://doi.org/10.1016/j.ejpb.2026.115099
  79. Sikder, A.; Katarpawar, S. N.; Kumar, R.; Phatale, V.; Vambhurkar, G.; Pandey, G.; Srivastava, S. QbD-Based Intranasal pH-Sensitive Ibrutinib Liposomes for Glioblastoma Management: In Vitro, Ex Vivo, and In Vivo Pharmacokinetics and Brain Distribution Assessment. Eur. J. Pharm. Biopharm. 2026, 115121.
    https://doi.org/10.1016/j.ejpb.2026.115121
  80. Reang, K. T.; Suradkar, R. V.; Dikundwar, A. G.; Mondal, P. K.; Deb, P. K.; Venugopala, K. N.; Nayak, S. K. Molecular Dynamics, DFT, and Structural Studies of Acetyl Coumarin Derivatives Targeting Antimicrobial Proteins. J. Mol. Struct. 2026, 146825.
    https://doi.org/10.1016/j.molstruc.2026.146825

Book Chapters
  1. S. Gajula, S. Vora, A. G. Dikundwar, and R. Sonti. In vitro drug metabolism studies using human liver microsomes. IntechOpen, October 2022. https://doi.org/10.5772/intechopen.108246


PATENTS
PATENTS AND TECHNOLOGY TRANSFERS
  • Technology Transfer: Vorinostat Product Development - API to Formulation, in collaboration with the research team at NIPER Ahmedabad leading the project; transferred to Trident Lifeline, Ahmedabad, in March 2025.
  • Soluble drug delivery composition for leishmaniasis and method for synthesis thereof, Indian Patent No. 558001, dated 15 January 2025.
  • A method for generating Microcrystals using a Polymer-based Microdevice, Indian Patent No. 575832, dated 15 December 2025.
  • Crystallization process for selectively obtaining Needle, Plate and Block shaped crystal morphologies of a PDE inhibitor Tadalafil, Indian Patent No. 576820, dated 30 December 2025.
  • Novel Compounds and Their Pharmaceutical Application (in collaboration with Zydus Lifesciences Ltd.), Indian Patent Application No. 202421097002, filed on 09 December 2024.


INVITED TALKS
INVITED TALKS AND TRAININGS
Title / activityInvited byDate
Applications of Crystallography in Pharmaceutical SciencesCrystallography Workshop at M.S. Ramaiah Institute of Technology, Bangalore,July 2014
Detection and Quantification of Low Levels of Solid state Impurities by PXRD: A comparison with HPLCSatellite workshop on PXRD in Pharmaceutical and Materials Industry (ICDD), 46th National Seminar on Crystallography at NIMHANS, Bangalore, IndiaJune 2018
Solid Form Screening and Selection in Pharmaceutical Development: Implications on Materials Properties and Performance46th National Seminar on Crystallography at NIMHANS, Bangalore, IndiaJune 2018
Quality Risk Management in Pharmaceutical DevelopmentNational Institute of Micro, Small and Medium Enterprises (NIMSME), HyderabadOctober 2021
Sponsored Research-Opportunities, Approaches and Financial Gains (Panelist)Sathguru Management Consultants in association with National Biopharma Mission, BIRAC (Venue: Hotel Mercure, Hyderabad)April 2022
TSCOST - Quality Assurance and Quality Control of PharmaceuticalsProgram coordinator, NIPER HyderabadJuly-October 2022
TSCOST - Entrepreneurship Development ProgramProgram coordinator, NIPER HyderabadAugust 2022
Overview of Analytical Capabilities with particular reference to solid state characterization and polymorph screeningNovartis, HyderabadSeptember 2022
9th Annual Symposium of Federation of Indian Physiological Societies 2022 (Jury panel member for students presentations)NIPER HyderabadMarch 2022
Nanomechanics for Pharmaceutical Applications (NPA) 2023 (Session Chair)Organizing Committee, NPA-2023 (Venue: Lemon Tree Premier Hitec City, Hyderabad)December 2023
TSCOST - Quality Assurance and Quality Control of PharmaceuticalsProgram coordinator, NIPER HyderabadDecember 2023-March 2024
Renishaw Raman Pharma Connect event, Renishaw Metrology Systems Limited, Pune (Resource Person)Renishaw Metrology Systems Limited, PuneOctober 2024
International Conference on “Frontiers in Physical and Chemical Science: Exploring New Horizons” (FPCS-2024), Acharya Institute of Graduate Studies, BangaloreAcharya Institute of Graduate Studies, BangaloreNovember 2024
Chemistry-Innovation and Translations in Drug Discovery (CITDD-2025), NIPER Ahmedabad (Session co-chair)NIPER AhmedabadFebruary 2025
Latest trends in Pharmaceutical Process & PAT SolutionsSpinco Limited, Hyderabad (Venue: Hotel The Park, Somajiguda, Hyderabad)March 2025
NDTL Annual Conference -2025 on "Anti-Doping Science: Innovations and Challenges," held at India International Centre, New Delhi (Panelist)National Dope Testing Laboratory (NDTL), New DelhiMarch 2025
Training Programs Conducted
  • Coordinated a series of training sessions as part of the USP India-NIPER Hyderabad joint workshop during April-June 2023.
  • Designed and delivered training sessions on “Solid State Characterization of Pharmaceuticals” for employees of Novartis India, Genome Valley, Hyderabad, in 2023, jointly with Dr. Sounik Saha from Novartis India.


SPONSORED PROJECTS
Government Sponsored Projects
Sr. No.Title of projectRoleFunding agencyAmount (Rs. Lakhs)Status
1Solid state characterization of Pharmaceuticals (Karyashala – Workshop Under Abhyaas scheme)PIDST-SERB4.00Completed
2Co-amorphous Forms for Bioavailability Enhancement of poorly Soluble Drugs: Design, Synthesis, Characterization and in-vivo studiesPIDST-SERB30.42Completed
3Institutional project on Trace Level Detection of Doping Agents in Nutritional SupplementsPIDepartment of Sports, Ministry of Youth Affairs and Sports, Government of India631.20Ongoing
4Institutional project on Surveillance on Food for Special Dietary Use (FSDU) for Sports PersonsPIFSSAI76.70Ongoing
5Evaluation of Drug Interaction Potential of Majooen-e-Dabeed-ul-Ward with Atorvastatin and Ours-e-Ziabetus Khaas with MetforminCo-PICCRUM43.66Ongoing
6Pharmacokinetic interaction of Majoon Najah with combination of (Carbidopa+Levodopa) and neuroprotective potential of Majoon Najah in haloperidol disease.Co-PICCRUM13.36Ongoing
Industry Sponsored Projects
Sr. No.Title of projectRoleFunding agencyAmount (Rs. Lakhs)Status
1Solid state characterization of modified solid-state forms of APIPIBristol Myers Squibb, USA7.44Completed
2Tracing a root cause for the formation of N-methyl impurity in NorfloxacinCo-PINakoda Chemicals Limited, Hyderabad1.80Completed
3Quantification of polymorphic impurity in Famotidine API (Consultancy Project)PINakoda Chemicals Limited, Hyderabad0.70Completed
5Formulation Development and Analytical Characterization of N-Acetyl Cysteine based antibiotic formulations as intrauterine dosage form for veterinary usePIHeka Pharmaceuticals Private Limited4.13Completed
6Customized analytical support to projects under institutes analytical services mode (Quantitative phase analysis by PXRD; Core size determination of complex metal based formulations by PXRD; Determination of collapse temperature and freezing point temperature for lyophilized dosage forms by Cryo-DSC/mDSC; Sameness study for complex generics by comparison with RLD by PXRD, FTIR and DSC; Absolute structure determination by 2D-NMR and Single Crystal XRD; Correlation of dissolution with phase analysis by Powder XRD; residual content by GC; Elemental impurities quantification by ICP-MS; Method development and validation for nitrosamine impurities using LC-MS/GC-MS; Elemental composition by HRMS, etc.)PINakoda Chemicals Limited; Orbicular Pharmacutical Technologies Pvt. Ltd.; DifGen Pharmaceuticals Pvt. Ltd.; Neuland Pharma; Metrochem API; Enal Drugs Pvt. Ltd.; Aurore Life Sciences; Saptagir Camphor Private Limited; Synthochem Pvt. Ltd.; SETV ASRV Pharma; etc.-Completed/ Ongoing
Laboratory facilities developed for research / teaching.
  • Establishment and maintenance of a full-fledged solid-state characterization laboratory involving design, procurement, installation, and maintenance of Powder XRD with SAXS attachment, Single Crystal XRD, DSC, TGA, and Crystal 16 parallel mini-reactor instruments.
  • Installation of ICP-MS, GC-MS, and SFC instruments and maintenance and upgradation of the analytical infrastructure, including deep freezers, humidity chambers, ovens, photostability chamber, sonicator, pH meter, and water-purification systems.
  • Establishment and maintenance of the Centre for Testing of Nutritional Supplements under a tripartite MoU with the Department of Sports and FSSAI, with technical guidance from NDTL and NADA; the centre hosts an LC-HRMS instrument.
  • Establishment and maintenance of a NABL-accredited analytical testing laboratory providing testing for external samples from industry, academia, and government agencies, and regulated-testing experience for students.

ADDITIONAL RESPONSIBILITIES
  • In-charge of the NABL-accredited (ISO/IEC 17025:2017) Analytical Testing Laboratory at NIPER Hyderabad and point of contact for analytical testing services to academia, industry, and government and regulatory agencies. The facility hosts the Centre for Testing of Nutritional Supplements and is gazette-notified by FSSAI as a primary and referral laboratory.
  • Institute representative for management of analytical services through the Indian Science Technology and Engineering Facilities Map (I-STEM).
  • Member of the committee overseeing the establishment and functioning of the Centre of Excellence in Bulk Drugs at NIPER Hyderabad.
  • Member of the Stores and Purchase Committee (SPC-I) overseeing procurement of consumables at NIPER Hyderabad.


ANY OTHER INFORMATION
  • Associate Member - International Centre for Diffraction Data (ICDD)
  • Member - Indian Crystallographic Association (ICA)
  • Member - Marathi Vidnyan Parishad, Mumbai
  • Member - Scientific Advisory Committee and Project Monitoring Committee, Avishkaran - A Bionest incubator at NIPER Hyderabad