Publications are the primary method for reporting and long-term documentation of the research conducted at the NIPER-Hyderabad. Here the list of publications published in year wise...

1. Kumawat, A.; Ambati, H.; Galla, M. S.; Kuralkar, K.; M. Venkatesh; Ghosh, B.; Shankaraiah, N. β-Carbolines Linked γ-Amino Butyric Acid/p-Amino Benzoic Acid Based Carboxamides as Histone Deacetylase Inhibitors: Design, Synthesis, Cytotoxicity and In Silico Studies. International Journal of Biological Macromolecules 2025, 334, 149131. https://doi.org/10.1016/j.ijbiomac.2025.149131
2. Dastari, S.; Pasupuleti, V.; Madhurya, M. S.; Sharma, A.; Godugu, C.; Shankaraiah, N. Design, Synthesis, and Cytotoxicity Evaluation of Styrylspirooxindole Carboxamides as Potential Tubulin and VEGFR-2 Dual Inhibitors. ChemMedChem 2025, 20, e202500634. https://doi.org/10.1002/cmdc.202500634
3. Khan, M. A.; Saha, S.; Sakla, A. P.; Sathish, M.; Shankaraiah, N. Metal-Free Amination of Imidazoheteroarenes Employing p-Quinone Diimides (p-QDIs). ChemistrySelect 2025, 10, e04429. https://doi.org/10.1002/slct.202504429
4. Khan, M. A.; Rallabandi, N. C.; Raman, P. K.; Sharma, A.; Godugu, C.; Shankaraiah, N. Design, Synthesis, and Cytotoxicity Evaluation of 1,2,3-Triazole-Linked β-Carboline–Benzimidazole Hybrids as Tubulin Polymerization Inhibitors. New Journal of Chemistry 2025, 49, 17716–17729. https://doi.org/10.1039/d5nj03098f
5. Chauhan, Y.; Kumawat, A.; Singh, A.; Shankaraiah, N.; Kaki, V. R. Unravelling the Potential of Small Molecule Tumor Necrosis Factor-α (TNF) Inhibitors: A Comprehensive Review. Bioorganic & Medicinal Chemistry 2025, 130, 118344. https://doi.org/10.1016/j.bmc.2025.118344
6. Dastari, S.; Pradhan, S.; Thakur, V.; Reddyrajula, R.; Chilvery, S.; Godugu, C.; Shankaraiah, N. Design, Synthesis and Biological Evaluation of Spirocyclopropyl Oxindole-Piperazine/Morpholine-Based Carboxamides as Potential Anticancer Agents. Bioorganic Chemistry 2025, 163, 108784. https://doi.org/10.1016/j.bioorg.2025.108784
7. Kumari, P.; Dastari, S.; Singitham, S.; Avvaru, S. J.; Shankaraiah, N. Regioselective Multi-Component Approach Promoted by p-TSA: A Facile Synthetic Access to 3,5-Disubstituted 4-Pyridinone Frameworks. Asian Journal of Organic Chemistry 2025, 14, e00445. https://doi.org/10.1002/ajoc.202500445
8. Kanp, T.; Dhuri, A.; Aalhate, M.; Manoharan, B.; Rode, K.; Munagalasetty, S.; Sarma, A. V. S.; Kshirsagar, P.; Shankaraiah, N.; Bhandari, V.; Sharma, B.; Singh, P. K. Investigation of a Palbociclib and Naringin Co-Amorphous System to Ameliorate Anticancer Potential: Insights on In Silico Modeling, Physicochemical Characterization, Ex Vivo Permeation, and In Vitro Efficacy. Molecular Pharmaceutics 2025, 22, 2446–2465. https://doi.org/10.1021/acs.molpharmaceut.4c01224
9. Dastari, S.; Panda, B.; Rasane, S.; Reddyrajula, R.; Godugu, C.; Shankaraiah, N. Design, Synthesis of 1H-Benzimidazol-2-yl-Enaminone Hybrids as Tubulin Polymerization Inhibitors and In Vitro Cytotoxicity Studies. SYNLETT 2025, 36, 2855–2863. https://doi.org/10.1055/s-0043-1775494
10. Gupta, S.; Galla, M. S.; Suhas, K. P.; Shankaraiah, N. Carboxylic Acids as Enabling Directing Groups in C-H Activation and Functionalization: A Decade Review. Advanced Synthesis & Catalysis 2025, 367, e202500093. https://doi.org/10.1002/adsc.202500093
11. Jha, A.; Dastari, S.; Barve, N. M.; Shankaraiah, N. Oximes and Hydrazones as Versatile Directing Groups: A Critical Review on Recent Advances of C-H Activation and Functionalization. Tetrahedron 2025, 179, 134634. https://doi.org/10.1016/j.tet.2025.134634
12. Khan, M. A.; Parida, K. K.; Sowmya, D.; Rallabandi, N. C.; Kalia, N. P.; Shankaraiah, N. Design and Synthesis of β-Carboline-Benzofuran Based Hybrids as Antibacterial Agents Against Staphylococcus aureus. Bioorganic & Medicinal Chemistry Letters 2025, 123, 130220. https://doi.org/10.1016/j.bmcl.2025.130220
13. Reddyrajula, R.; Varshini, K. P.; Shankaraiah, N. Recent Developments of Benzimidazole Based Analogs as Potential Tubulin Polymerization Inhibitors: A Critical Review. Bioorganic & Medicinal Chemistry Letters 2025, 122, 130167. https://doi.org/10.1016/j.bmcl.2025.130167
14. Valapil, D. G.; Devabattula, G.; Barahdia, A. S.; Godugu, C.; Shankaraiah, N. Development of 3-Indolyl Substituted Phenyl Pyrazolo-Carboxamide Hybrids as Potential Type II VEGFR-2 Inhibitors and In Vitro Cytotoxicity Studies. Bioorganic & Medicinal Chemistry Letters 2025, 117, 130070. https://doi.org/10.1016/j.bmcl.2024.130070
15. Golla, V. M.; Chary, P. S.; Naik, D. D.; Pilli, P.; Kommalapati, H. S.; Ramteke, A.; Mehra, N. K.; Samanthula, G. Separation, identification, and characterization of transformation products related to relugolix upon subjecting to in vitro gastrointestinal fluids utilizing liquid chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy. Separation Science Plus 2025, 8 (1), e202400195. https://doi.org/10.1002/sscp.202400195
16. Khemchandani, R.; Pardhi, E.; Goud, S.; Tomar, D. S.; Medtiya, P.; Khushwaha, B. S.; Dhiman, V.; Golla, V. M.; Shaikh, N.; Godugu, C. Multi-method coamorphous systems of lumefantrine with alpha ketoglutaric acid: Comprehensive characterization, biological evaluation and stability analysis. International Journal of Pharmaceutics 2025, 669, 125056. https://doi.org/10.1016/j.ijpharm.2024.125056
17. Pilli, P.; Chaganti, S.; Golla, V. M.; Kommalapati, H. S.; Nayak, B. V.; Samanthula, G. Separation of Oxidative Degradation Products of the Anti-Cancer Drug Gilteritinib Fumarate by Liquid Chromatography with Photodiode Array and Mass Spectrometric Detection. Journal of Analytical Chemistry 2025, 80 (4), 684–692. https://doi.org/10.1134/S106193482570011X
18. Mouli, H. C.; Harini, D.; Shaikh, N.; Khemchandani, R.; Shreya, S.; Jana, A.; Samanthula, G. In silico characterization of indole-substituted densely functionalized pyrrole against breast cancer: Integrating DFT, molecular docking, MD simulations, and ADME analysis. Journal of Molecular Structure 2025, 1328, 141375. https://doi.org/10.1016/j.molstruc.2025.141375
19. Dande, A.; Chandra Mouli, H.; Nandy, J.; Shreya, S.; Pallaprolu, N.; Samanthula, G.; P, R. Risk assessment, detection and control of mutagenic impurities in pharmaceuticals: Emphasis on nitrosamines. Critical Reviews in Analytical Chemistry 2025, 1–42. https://doi.org/10.1080/10408347.2025.2517357
20. Dhiman, V.; Khemchandani, R.; Velip, L.; Mishra, D.; Samanthula, G. Understanding the degradation behavior of masitinib by Stress testing, UHPLC, HRMS, NMR, APCI-MS, DFT and prediction of toxicity using in silico tools. Journal of Pharmaceutical Sciences 2025, 103958. https://doi.org/10.1016/j.xphs.2025.103958
21. Jain, J. K.; Sujatha, K.; Sheelarani, T.; Trivedi, H.; Khemchandani, R.; Gananadhamu, S. Analytical Quality by Design Enabled Green RP-HPLC Method Development and Validation for the Simultaneous Quantitation of the Cleaning Residues of Osimertinib, Binimetinib, and Erdafitinib: An Approach to Prevent the Cross-Contamination in Shared Facilities of Pharmaceutical Manufacturing. Separation Science Plus 2025, 8 (9), e70102. https://doi.org/10.1002/sscp.70102
22. Golla, V. M.; Pilli, P.; Padhy, H. P.; Samanthula, G.; Gupta, A. K. Analytical challenges in the mavacamten impurity analysis: Exploring various cutting edge analytical methods to achieve mass balance for the accurate quantification of analytes. Journal of the Indian Chemical Society 2025, 102082. https://doi.org/10.1016/j.jics.2025.102082
23. Chaganti, S.; Shaikh, N.; Pimpre, K.; Barik, P.; Jadhav, A.; Chilvery, S.; Talari, K.; Godugu, C.; Samanthula, G. Structural characterization of in vivo and in vitro metabolites of bosutinib by LC-MS/MS, in combination with the in silico methodologies for toxicity and metabolism prediction. Drug Metabolism and Disposition 2025, 100161. https://doi.org/10.1016/j.dmd.2025.100161
24. Chaganti, S.; Chauhan, U.; Harini, D.; Mouli, H. M. C.; Nayak, B. V.; Samanthula, G. Stress Degradation Study of Bosutinib and Structural Elucidation of Its Degradation Impurities by Using LC-Q-TOF-MS/MS and NMR. Journal of Mass Spectrometry 2025, 60 (10), e5180. https://doi.org/10.1002/jms.5180
25. Khemchandani, R.; Pardhi, E.; Jadhav, A.; Devi, P.; Roshitha, K.; Bhatt, N.; Godugu, C.; Mehra, N. K.; Samanthula, G. Integrated experimental, computational and machine learning approaches for the development of Apremilast-Aceclofenac coamorphous systems. International Journal of Pharmaceutics 2025, 126283. https://doi.org/10.1016/j.ijpharm.2025.126283
26. Bhatt, N.; Sonaje, D.; Golla, V. M.; Khemchandani, R.; Gupta, A. K.; Samanthula, G. Identification and characterization of forced degradation products of lumateperone tosylate by LC-HRMS, GC-MS, NMR, and in silico toxicity prediction. Journal of Pharmaceutical and Biomedical Analysis Open 2025, 6, 100085. https://doi.org/10.1016/j.jpbao.2025.100085
27. Singh, P.; Samanthula, G.; Jasti, M. C.; Ramchandran, R. K.; Kodam, C.; Suraj; Singh, N.; Bhadoriya, K. Targeted Ultra-High Performance Liquid Chromatography–Electrospray Ionization Triple Quadrupole Mass Spectrometry-Based Quantification of Diosgenin in Hellenia speciosa for Its Wild Populations Screening: A Quality Control Assessment. Separation Science Plus 2025, 8 (12), e70167. https://doi.org/10.1002/sscp.70167
28. Jain, J. K.; Sujatha, K.; Sheelarani, T.; Trivedi, H.; Khemchandani, R.; Gananadhamu, S. An Eco-Friendly and Quality-by-Design Optimized Synchronous Spectrofluorescence Method for the Simultaneous Determination of Cleaning Residues of Anticancer Drugs Darolutamide and Enzalutamide From Manufacturing Surfaces. Luminescence 2025, 40 (12), e70376. https://doi.org/10.1002/bio.70376
29. Kumar, M.; Arya, D. K.; Almujri, S. S.; Chidambaram, K.; Pandey, P.; Kumar, A.; Pandey, G.; Sharma, A.; Chaurasiya, M.; Babu, M. A.; Kumar, R. V.; Gupta, R. K.; Srivastava, S.; Rajinikanth, P. S. Mulberry Silk Worm Pupae Oil and Prussian Blue Nanoparticle Enriched Multi-Faceted Polyvinyl Alcohol Nanofiber for Infectious Full Thickness Skin Wound Healing. Tissue Engineering and Regenerative Medicine 2025, 22, 1119–1140. https://doi.org/10.1007/s13770-025-00751-8
30. Pandey, G.; Famta, P.; Shah, S.; Kumar, R.; Wagh, S.; Vambhurkar, G.; Sharma, A.; Sharma, A.; Shinde, S.; Singh, G.; Chandankar, S.; Dalal, A.; Kalia, N. P.; Asthana, A.; Srivastava, S. Disulfiram-Encapsulated Poly(caprolactone) Nanofiber Scaffolds for Oral Squamous Cell Carcinoma Management. Bionanoscience 2025, 15. https://doi.org/10.1007/s12668-025-02153-5
31. Joga, R.; Vambhurkar, G.; Srivastava, S. Regulatory Science-Aligned Development and Pre-Clinical Evaluation of Novel Lidocaine-Loaded Nanoemulgel for Psoriasis Management. Journal of Investigative Dermatology 2025, 145, e64. https://doi.org/10.1016/j.jid.2025.09.218
32. Gandhi, K.; Joga, R.; Sowndharya, M.; Vijay, G. K.; Waiker, S.; Yerram, S.; Raghuvanshi, R. S.; Srivastava, S. Unlocking Generic Market Access: A Retrospective Analysis of USFDA Paragraph IV Filings (2020–2024). Therapeutic Innovation & Regulatory Science 2025, 59, 1380–1393. https://doi.org/10.1007/s43441-025-00831-w
33. Joga, R.; Yerram, S.; Patnam, J. D.; Choudhary, K. K.; Varpe, P.; Raghuvanshi, R. S.; Srivastava, S. Unraveling the Policies, Legislations, and Regulations of Psychedelics in Australia, Canada, Netherlands, New Zealand, and India. Health Policy 2025, 161, 105392. https://doi.org/10.1016/j.healthpol.2025.105392
34. Ahmad, A.; Simran, S.; Kalokhe, V. M.; Musthafa, F.; Gangawane, V. S.; Choudhary, K. K.; Raghuvanshi, R. S.; Srivastava, S. Genetic Renaissance: A Cross-Regional Analysis of the Approval Landscape of Authorised Gene Therapeutics in Paediatrics, Challenges and Future Prospects. Journal of Community Genetics 2025, 16, 513–528. https://doi.org/10.1007/s12687-025-00799-y
35. Prasad, S. B.; Shinde, A.; Srinivasarao, D. A.; Famta, P.; Shah, S.; Kolipaka, T.; Pandey, G.; Gaonker, D.; Vambhurkar, G.; Khairnar, P.; Kumar, R.; Dikundwar, A. G.; Kanchupalli, V.; Srivastava, S. Metal-Organic Frameworks as Therapeutic Chameleons: Revolutionizing the Cancer Therapy Employing Novel Nanoarchitectonics. Asian Journal of Pharmaceutical Sciences 2025, 20, 101054. https://doi.org/10.1016/j.ajps.2025.101054
36. Prasannanjaneyulu, V.; Nene, S.; Vambhurkar, G.; Tryphena, K. P.; Khatri, D. K.; Srivastava, S. Amelioration of Imiquimod-Induced Psoriasis in the Mice Model by Topical Delivery of Phosphodiesterase 4 Inhibitor Roflumilast Incorporated Nanoemulgel. Pharmaceutical Development and Technology 2025, 30, 1083–1093. https://doi.org/10.1080/10837450.2025.2505004
37. Jain, A.; Kolipaka, T.; Pandey, G.; Priyadarshinee, A.; Puri, N.; Shinde, S.; Srivastava, S. Innovative Approaches to Diabetic Wound Healing: Focusing on ROS and Redox Signals. Molecular Pharmaceutics 2025, 22, 5738–5766. https://doi.org/10.1021/acs.molpharmaceut.5c00491
38. Bahuguna, D.; Amulya, E.; Arya, S.; Loharkar, S.; Vambhurkar, G.; Bhattacharjee, S.; Chandanapalli, D. K.; Madan, J.; Srivastava, S. Unlocking Therapeutic Potential in Traumatic Brain Injury: Exploring Microenvironmental Targets, Signaling Pathways and Translational Hurdles. Inflammopharmacology 2025, 33, 5113–5144. https://doi.org/10.1007/s10787-025-01923-7
39. Sowndharya, M.; Joga, R.; Gandhi, K.; Vijay, G. K.; Waikar, S.; Yerram, S.; Raghuvanshi, R. S.; Srivastava, S. Navigating the Trends in USFDA Authorized Generic Approvals (2019–2024): Enhancing Healthcare Accessibility and Affordability. Therapeutic Innovation & Regulatory Science 2025, 59, 1053–1063. https://doi.org/10.1007/s43441-025-00806-x
40. Famta, P.; Shah, S.; Vambhurkar, G.; Kumar, R.; Pandey, G.; Singh, G.; Wagh, S.; Arya, D. K.; Kanaujiya, S.; Sharma, A.; Prasad, S. B.; Shinde, A.; Chandankar, S.; Shinde, S.; Sharma, A.; Rajinikanth, P. S.; Kalia, N. P.; Asthana, A.; Srivastava, S. Establishment and Evaluation of Paclitaxel and Simvastatin-Laden Nanofibers for Post-Surgical Tumor Recurrence in Breast Cancer. Bionanoscience 2025, 15. https://doi.org/10.1007/s12668-025-01935-1
41. Khairnar, P.; Kolipaka, T.; Pandey, G.; Phatale, V.; Hedaoo, A.; Srivastava, S. Formulating Pharma-, Nutra-, and Cosmeceutical Products from Herbal Substances. Formulating Pharma-, Nutra-, and Cosmeceutical Products from Herbal Substances: Dosage Forms and Delivery Systems 2025, 299–321. https://doi.org/10.1002/9781119769484.ch11
42. Abraham, N.; Kolipaka, T.; Pandey, G.; Arya, D. K.; Sharma, A.; Vambhurkar, G.; Kumar, R.; Rajinikanth, P. S.; Srivastava, S. Quality by Design (QbD) Accredited Naringenin-Loaded Chitosan Nanoparticles Impregnated Gel for Diabetic Wound Healing: Formulation, Optimization, In Silico and In Vitro Characterization. Journal of Drug Delivery Science and Technology 2025, 114, 107418. https://doi.org/10.1016/j.jddst.2025.107418
43. Sharma, A.; Shah, S.; Wagh, S.; Pandey, G.; Pradhan, A. K.; Shukla, S.; Thomas, S. P.; Dikundwar, A. G.; Srivastava, S. Ever-Increasing Role of Computational Tools in Solid-State Pharmaceutics: Advancing Drug Development with Enhanced Molecular Understanding and Risk Assessment. Molecular Pharmaceutics 2025, 22, 5165–5192. https://doi.org/10.1021/acs.molpharmaceut.5c00296
44. Phatale, V.; Khairnar, P.; Shukla, S.; Puri, N.; Sahane, P.; Srivastava, S. Nano-Biohybrids with Cell-Penetrating Peptides: A Molecular Trojans for Glioblastoma Precision Medicine. International Journal of Pharmaceutics 2025, 683, 126077. https://doi.org/10.1016/j.ijpharm.2025.126077
45. Sahane, P.; Khairnar, P.; Hedaoo, A.; Shukla, S.; Puri, N.; Phatale, V.; Prasad, S. B.; Shinde, A.; Vambhurkar, G.; Srivastava, S. Hyaluronic Acid-Infused Microneedles: Unlocking the Revolutionary Era of Targeted Melanoma Treatment. European Polymer Journal 2025, 238, 114205. https://doi.org/10.1016/j.eurpolymj.2025.114205
46. Famta, P.; Shah, S.; Sharma, A.; Vambhurkar, G.; Singh, Y.; Mourya, A.; Srinivasarao, D. A.; Prasad, S. B.; Shinde, A.; Pandey, G.; Thareja, S.; Madan, J.; Srivastava, S. Hydroxy Propyl β-Cyclodextrin Complexes of Olaparib: Amalgamation of In Silico, In Vitro and In Vivo Approaches for Bioavailability Enhancement. Journal of Molecular Structure 2025, 1336, 142077. https://doi.org/10.1016/j.molstruc.2025.142077
47. Konda, P.; Yerram, S.; Khader, M. N.; Joga, R.; Nizam, M. V. P.; Girhe, M.; A. C. S.; Srivastava, S. USFDA Warning Letters: An Analysis of Compliance in Over-the-Counter Drug Products (2020–2024). Journal of Pharmaceutical Innovation 2025, 20. https://doi.org/10.1007/s12247-025-10061-0
48. Musthafa, F.; Simran, S.; Gangawane, V. S.; Kalokhe, V. M.; Ahmad, A.; Srivastava, S. The Evolution of Turbocharged Cancer Therapeutics: How Regulatory Flexibility Has Driven Accelerated Cancer Biologics Approvals in the United States (1993–2023). Journal of Pharmaceutical Innovation 2025, 20. https://doi.org/10.1007/s12247-025-10059-8
49. Jain, N.; Shahrukh, S.; Famta, P.; Shah, S.; Vambhurkar, G.; Srinivasarao, D. A.; Sharma, A.; Pandey, G.; Wagh, S.; Shinde, S.; Khan, A.; Kumar, P.; Srivastava, S. Combating Breast Cancer-Associated Metastasis Using Paclitaxel and Tranilast-Loaded Human Serum Albumin Nanoparticles. Drug Development and Industrial Pharmacy 2025, 51, 786–798. https://doi.org/10.1080/03639045.2025.2509861
50. Mourya, A.; Kumar, S.; Shah, S.; Famta, P.; Kanchupalli, V.; Srivastava, S.; Madan, J. Quality-by-Design-Assisted Laboratory Scale-Up of Lipid Nanoparticles of Stearic Acid-Raloxifene Hydrochloride Conjugate: A Pathway for Enhanced Oral Bioavailability via Lymphatic Uptake. Molecular Pharmaceutics 2025, 22, 3868–3884. https://doi.org/10.1021/acs.molpharmaceut.5c00139
51. Wagh, S.; Khairnar, P.; Pandey, G.; Phatale, V.; Srivastava, S. Minimally Invasive Injectable Hydrogels. Transdermal Applications of Minimally Invasive Drug Delivery Systems: Current Trends and Future Perspectives 2025, 23–51. https://doi.org/10.1007/978-981-96-6275-3_2
52. Kolipaka, T.; Amulya, E.; Vambhurkar, G.; Shukla, S.; Srivastava, S. Introduction to Minimally Invasive Drug Delivery System (MIDDS). Transdermal Applications of Minimally Invasive Drug Delivery Systems: Current Trends and Future Perspectives 2025, 1–21. https://doi.org/10.1007/978-981-96-6275-3_1
53. Nizam, V. P. M.; Yerram, S.; Ajmal, C. S.; Raghuvanshi, R. S.; Srivastava, S. Unraveling Trends in USFDA’s CDER-Regulated Drug Shortages (2019–2024): Causes, Patterns, and Strategic Insights for the Future. Journal of Pharmaceutical Innovation 2025, 20. https://doi.org/10.1007/s12247-025-10009-4
54. Shah, S.; Famta, P.; Kumar, R.; Vambhurkar, G.; Pandey, G.; Shinde, A.; Prasad, S. B.; Sharma, A.; Sharma, A.; Kanaujiya, S.; Arya, D. K.; Kolipaka, T.; Wagh, S.; Rajinikanth, P. S.; Srivastava, S. QbD Manoeuvred Niclosamide Laden Polylactic-co-Glycolic Acid Nanoparticles-Impregnated Gelatin Nanofibers for the Management of Oral Carcinoma. Bionanoscience 2025, 15. https://doi.org/10.1007/s12668-025-01833-6
55. Nene, S.; Devabattula, G.; Vambhurkar, G.; Tryphena, K. P.; Khatri, D. K.; Godugu, C.; Singh, P. K.; Srivastava, S. Topical Delivery of Baricitinib-Impregnated Nanoemulgel: A Promising Platform for Inhibition of JAK-STAT Pathway for the Effective Management of Atopic Dermatitis. Drug Delivery and Translational Research 2025, 15, 2200–2219. https://doi.org/10.1007/s13346-024-01732-5
56. Shinde, S.; Shah, S.; Famta, P.; Wagh, S.; Pandey, G.; Sharma, A.; Vambhurkar, G.; Jain, A.; Srivastava, S. Next-Generation Transformable Nanomedicines: Revolutionizing Cancer Drug Delivery and Theranostics. Molecular Pharmaceutics 2025, 22, 2783–2806. https://doi.org/10.1021/acs.molpharmaceut.4c01495
57. Wangmo, T.; Garg, K.; Ibrahim, A. A.; Srivastava, S.; Famta, P.; Singh, S. K.; Gulati, M.; Dua, K.; Kaur, J. Oral Insulin Delivery by Spatiotemporal Polymeric Micelles: Existing Barriers, Status Quo and Opportunities. European Polymer Journal 2025, 233, 113981. https://doi.org/10.1016/j.eurpolymj.2025.113981
58. Sahane, P.; Puri, N.; Khairnar, P.; Phatale, V.; Shukla, S.; Priyadarshinee, A.; Srivastava, S. Harnessing Folate Receptors: A Comprehensive Review on the Applications of Folate-Adorned Nanocarriers for the Management of Melanoma. ACS Applied Bio Materials 2025, 8, 3623–3656. https://doi.org/10.1021/acsabm.5c00077
59. Puri, N.; Sahane, P.; Phatale, V.; Khairnar, P.; Shukla, S.; Priyadarshinee, A.; Jain, A.; Srivastava, S. Nano-Chameleons: A Review on Cluster of Differentiation-Driven Immune Cell-Engineered Nanoarchitectonics for Non-Small Cell Lung Cancer. International Journal of Biological Macromolecules 2025, 310, 143440. https://doi.org/10.1016/j.ijbiomac.2025.143440
60. Priyadarshinee, A.; Amulya, E.; Vambhurkar, G.; Jain, A.; Puri, N.; Sahane, P.; Srivastava, S. Unveiling the Revolutionary Approach for Psoriasis Management: Leveraging the Breakthrough Capabilities of Hyaluronic Acid. International Journal of Biological Macromolecules 2025, 310, 143089. https://doi.org/10.1016/j.ijbiomac.2025.143089
61. Jaiswal, P.; Pandey, G.; Kumar, S.; Kolipaka, T.; Misra, S. K.; Kanaujiya, S.; Rajinikanth, P. S.; Srivastava, S.; Yadav, A. K. Advancements in Skin Tissue Regeneration: Unveiling Emerging Treatment Strategies, Regulatory Perspectives, and Future Directions for Enhanced Healing. Journal of Drug Delivery Science and Technology 2025, 108, 106872. https://doi.org/10.1016/j.jddst.2025.106872
62. Arya, D. K.; Pandey, P.; Kumar, A.; Chidambaram, K.; Al Fatease, A.; Pandey, G.; Srivastava, S.; Rajinikanth, P. S. Dual-Ligand Functionalized Liposomes with iRGD/Trastuzumab Co-Loaded with Gefitinib and Lycorine for Enhanced Metastatic Breast Cancer Therapy. Journal of Liposome Research 2025, 35, 173–187. https://doi.org/10.1080/08982104.2025.2457453
63. M, S.; Joga, R.; Gandhi, K.; Yerram, S.; Raghuvanshi, R. S.; Srivastava, S. Exploring the Clinical Trials, Regulatory Insights, and Challenges of PROTACs in Oncology. Seminars in Oncology 2025, 52, 152339. https://doi.org/10.1016/j.seminoncol.2025.152339
64. Tandulje, A. A.; Varpe, P. C.; Chaugule, P. D.; Saji, S.; Nizar, F.; Raghuvanshi, R. S.; Srivastava, S. Cell and Gene Therapy Products: Navigating the Regulatory Landscape of Paradigm Approvals in the US (2020 to 2024). Journal of Pharmaceutical Innovation 2025, 20. https://doi.org/10.1007/s12247-025-09973-8
65. Girhe, M. K.; Yerram, S.; Ajmal, S. C.; Muhammed Nizam, V. P.; Joga, R.; Khader, N.; Konda, P.; Raghuvanshi, R. S.; Srivastava, S. Enhancing Pharmaceutical Accessibility: Evaluating the Impact of Competitive Generic Therapy Exclusivity on Rapid Access of Generics into the U.S. Market (2019–2024). Journal of Pharmaceutical Innovation 2025, 20. https://doi.org/10.1007/s12247-025-09969-4
66. Kalokhe, V. M.; Simran, S.; Ahmad, A.; Musthafa, F.; Gangawane, V. S.; Raghuvanshi, R. S.; Srivastava, S. Unveiling Gaps and Demographic Influences in Alzheimer’s Therapy: A Data-Centric Study of FDA-Approved Late-Phase Clinical Trials. Neurological Sciences 2025, 46, 3085–3095. https://doi.org/10.1007/s10072-025-08135-5
67. Pandey, G.; Kolipaka, T.; Srinivasarao, D. A.; Abraham, N.; Jain, A.; Srivastava, S. Navigating the Complexities of Diabetic Foot Ulcers: From Pathophysiology to Advanced Treatment Strategies. Journal of Drug Delivery Science and Technology 2025, 107, 106852. https://doi.org/10.1016/j.jddst.2025.106852
68. Kanaujia, K. A.; Wagh, S.; Pandey, G.; Phatale, V.; Khairnar, P.; Kolipaka, T.; Rajinikanth, P. S.; Saraf, S. A.; Srivastava, S.; Kumar, S. Harnessing Marine Antimicrobial Peptides for Novel Therapeutics: A Deep Dive into Ocean-Derived Bioactives. International Journal of Biological Macromolecules 2025, 307, 142158. https://doi.org/10.1016/j.ijbiomac.2025.142158
69. Shukla, S.; Khairnar, P.; Hedaoo, A.; Phatale, V.; Vambhurkar, G.; Wagh, S.; Sharma, A.; Srivastava, S. Harnessing Peptide-Based Nanotherapeutics: Pioneering Melanoma Management from Diagnosis to Theranostics. Journal of Drug Delivery Science and Technology 2025, 107, 106811. https://doi.org/10.1016/j.jddst.2025.106811
70. Shah, S.; Famta, P.; Vambhurkar, G.; Sharma, A.; Mourya, A.; Srinivasarao, D. A.; Shinde, A.; Prasad, S. B.; Pandey, G.; Madan, J.; Srivastava, S. Exploration of Abiraterone Acetate Loaded Nanostructured Lipid Carriers for Bioavailability Improvement and Circumvention of Fast-Fed Variability. Drug Delivery and Translational Research 2025, 15, 1074–1091. https://doi.org/10.1007/s13346-024-01657-z
71. Bellapu, K. K.; Mergu, T.; Shirsath, N. V.; Shende, P. A.; Vasu, P. Y.; Jindal, D.; Grover, P.; Srivastava, S.; Sindhu, R. K.; Kumar, S. Regulatory Aspects of Antioxidants. Antioxidants: Nature’s Defense against Diseases 2025, 613–628. https://doi.org/10.1002/9781394270576.ch19
72. Wagh, S. S.; Famta, P.; Shah, S.; Vambhurkar, G.; Pandey, G.; Sikder, A.; Singh, G.; Shukla, S.; Sharma, A.; Prasad, S. B.; Shinde, A.; Kumar, R.; Kalia, N. P.; Raghuvanshi, R. S.; Srivastava, S. Navigating the Brain: Harnessing Endogenous Cellular Hitchhiking for Targeting Neoplastic and Neuroinflammatory Diseases. Asian Journal of Pharmaceutical Sciences 2025, 20, 101040. https://doi.org/10.1016/j.ajps.2025.101040
73. Abraham, N.; Pandey, G.; Kolipaka, T.; Negi, M.; Srinivasarao, D. A.; Srivastava, S. Exploring Advancements in Polysaccharide-Based Approaches: The Cornerstone of Next-Generation Cartilage Regeneration Therapeutics. International Journal of Biological Macromolecules 2025, 306, 141352. https://doi.org/10.1016/j.ijbiomac.2025.141352
74. Gupta, R.; Pandey, G.; Kumar, A.; Kapoor, A.; Wagh, S.; Kolipaka, T.; Famta, P.; Mishra, A.; Srivastava, S.; Misra, S. K. Harnessing Electrospun Nanofibers for Comprehensive Oral Disease Management: Current Trends and Future Perspectives. Journal of Drug Delivery Science and Technology 2025, 106, 106681. https://doi.org/10.1016/j.jddst.2025.106681
75. Shah, S.; Famta, P.; Vambhurkar, G.; Kumar, R.; Pandey, G.; Singh, G.; Wagh, S.; Kanaujiya, S.; Arya, D. K.; Sharma, A.; Shinde, A.; Prasad, S. B.; Chandankar, S.; Shinde, S.; Sharma, A.; Rajinikanth, P. S.; Khatri, D. K.; Asthana, A.; Srivastava, S. Docetaxel and Niclosamide-Loaded Nanofiber Systems for Improved Chemo-Therapeutic Activity and Resistance Reversal in Prostate Cancer. Drug Development and Industrial Pharmacy 2025, 51, 132–143. https://doi.org/10.1080/03639045.2025.2453533
76. Singh, G.; Famta, P.; Shah, S.; Vambhurkar, G.; Pandey, G.; Kumar, R.; Kumar, P.; Mourya, A.; Madan, J.; Srivastava, S.; Khatri, D. K. Nanoparticle-Enhanced Delivery of Resveratrol for Targeted Therapy of Glioblastoma: Modulating the Akt/GSK-3β/NF-kB Pathway in C6 Glioma Cells. Brain Research 2025, 1848, 149411. https://doi.org/10.1016/j.brainres.2024.149411
77. Srinivasarao, D. A.; Shah, S.; Famta, P.; Vambhurkar, G.; Jain, N.; Pindiprolu, S. K. S. S.; Sharma, A.; Kumar, R.; Padhy, H. P.; Kumari, M.; Madan, J.; Srivastava, S. Unravelling the Role of Tumor Microenvironment Responsive Nanobiomaterials in Spatiotemporal Controlled Drug Delivery for Lung Cancer Therapy. Drug Delivery and Translational Research 2025, 15, 407–435. https://doi.org/10.1007/s13346-024-01673-z
78. Famta, P.; Shah, S.; Vambhurkar, G.; Pandey, G.; Bagasariya, D.; Kumar, K. C.; Prasad, S. B.; Shinde, A.; Wagh, S.; Srinivasarao, D. A.; Kumar, R.; Khatri, D. K.; Asthana, A.; Srivastava, S. Amelioration of Breast Cancer Therapies through Normalization of Tumor Vessels and Microenvironment: Paradigm Shift to Improve Drug Perfusion and Nanocarrier Permeation. Drug Delivery and Translational Research 2025, 15, 389–406. https://doi.org/10.1007/s13346-024-01669-9
79. Famta, P.; Shah, S.; Dey, B.; Kumar, K. C.; Bagasariya, D.; Vambhurkar, G.; Pandey, G.; Sharma, A.; Srinivasarao, D. A.; Kumar, R.; Guru, S. K.; Raghuvanshi, R. S.; Srivastava, S. Despicable Role of Epithelial–Mesenchymal Transition in Breast Cancer Metastasis: Exhibiting De Novo Restorative Regimens. Cancer Pathogenesis and Therapy 2025, 3, 30–47. https://doi.org/10.1016/j.cpt.2024.01.001
80. Ajmal, C. S.; Yerram, S.; Abishek, V.; Nizam, V. P. M.; Aglave, G.; Patnam, J. D.; Raghuvanshi, R. S.; Srivastava, S. Innovative Approaches in Regulatory Affairs: Leveraging Artificial Intelligence and Machine Learning for Efficient Compliance and Decision-Making. The AAPS Journal 2025, 27. https://doi.org/10.1208/s12248-024-01006-5
81. Sikder, A.; Pasupuleti, V.; Khairnar, P.; Phatale, V.; Amulya, E.; Wagh, S. S.; Negi, M.; Asthana, A.; Raghuvanshi, R. S.; Khatri, D. K.; Srivastava, S. Deciphering Convection Enhanced Delivery: A Paradigm Shift for Circumventing Glioblastoma Multiforme. Journal of Drug Delivery Science and Technology 2025, 103, 106398. https://doi.org/10.1016/j.jddst.2024.106398
82. Chaugule, P. D.; Varpe, P. C.; Tandulje, A. A.; Raghuvanshi, R. S.; Srivastava, S. Expedited Pathway Insights: Unveiling Oncology and Non-Oncology Drug Approvals and Withdrawals of USFDA and EMA. Critical Reviews in Oncology/Hematology 2025, 205, 104539. https://doi.org/10.1016/j.critrevonc.2024.104539
83. Shah, S.; Famta, P.; Sharma, A.; Kumar, R.; Pandey, G.; Vambhurkar, G.; Srinivasarao, D. A.; Shinde, A.; Prasad, S. B.; Asthana, A.; Srivastava, S. Quality by Design Empowered Preparation of Itraconazole Albumin Nanoparticles for Prostate Cancer. Drug Delivery and Translational Research 2025, 15, 253–268. https://doi.org/10.1007/s13346-024-01592-z
84. Nene, S.; Devabattula, G.; Vambhurkar, G.; Tryphena, K. P.; Singh, P. K.; Khatri, D. K.; Godugu, C.; Srivastava, S. High Mobility Group Box 1 Cytokine Targeted Topical Delivery of Resveratrol Embedded Nanoemulgel for the Management of Atopic Dermatitis. Drug Delivery and Translational Research 2025, 15, 134–157. https://doi.org/10.1007/s13346-024-01565-2
85. Reddy, G. N.; Gottimukkula, B. R.; Bhalerao, H. A.; Talari, K.; Sonti, R. Metabolite Identification of Ripretinib by UPLC-ESI-MS/MS: In Silico Prediction, In Vitro Metabolism, and Stability Assessment. Food and Chemical Toxicology 2025, 206, 115761. https://doi.org/10.1016/j.fct.2025.115761
86. Reddy, G. N.; Palepu, M. S. K.; Sonti, R. LC-MS/MS-Based Investigation of Pharmacokinetic Interactions Between CYP3A4 Substrates Enzalutamide and Repaglinide in Rats. RSC Analytical Methods 2025, 17, 9565. https://doi.org/10.1039/d5ay01451d
87. Dhurjad, P.; Bazaz, R.; Pati, S.; Dandekar, M. P.; Godugu, C.; Sonti, R. Structure and Activity of Conopressins: Insights into In Silico Oxytocin/V2 Receptor Interactions, Anti-Inflammatory Potential, and Behavioural Studies. RSC Medicinal Chemistry 2025, 16, 4106. https://doi.org/10.1039/d5md00288e
88. Singampalli, A.; Bandela, R.; Bakchi, B.; Maddipatla, S.; Kumar, P.; Bellapukonda, S. M.; Agnivesh, P. K.; Parida, K. K.; Giovannuzzi, S.; Biernacki, K.; Bonardi, A.; Gratteri, P.; Bhalerao, H. A.; Sonti, R.; Nanduri, S.; Supuran, C. T.; Kalia, N. P.; Yaddanapudi, M. V. Exploring Indole-Linked Triazole Sulfonamide Derivatives as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Leveraging a Tail Approach for the Design, Synthesis, and In Silico Studies—An In-Depth Multidisciplinary Study. Journal of Medicinal Chemistry 2025, 68, 18370–18388. https://doi.org/10.1021/acs.jmedchem.5c01026
89. Dhurjad, P.; Dannarm, S. R.; Shaik, K.; Wanjari, P.; Sonti, R. Conformational Heterogeneity of Pro-Pro Containing 23-Membered Ring Conopeptides by NMR. ACS Omega 2025, 10, 54030. https://doi.org/10.1021/acsomega.5c05404
90. Krishnappa, R.; Shit, S.; Dey, P.; Nayak, A.; Sahoo, D. K.; Shaik, K.; Sonti, R.; Raghothama, S.; Gowd, K. H. Comparative Study of UVA Filtering Compounds 2-Methyl/2-Amino Pyrimidine Derivatives of Avobenzone under Acidic Conditions. ACS Omega 2025, 10, 50139–50152. https://doi.org/10.1021/acsomega.5c06701
91. Yadav, R.; Chary, P. K.; Bhalerao, H.; Srivastava, V.; Pardhi, E.; Pawar, A.; Sonti, R.; Mehra, N. K. Nanotechnology-Driven Colorectal Cancer Treatment: Coencapsulation of Irinotecan and Cyclosporine A in SNEDDS for Superior Outcomes. ACS Applied Bio Materials 2025, 8, 5883. https://doi.org/10.1021/acsabm.5c00567
92. Ommi, O.; Bhalerao, H. A.; Malik, P.; Ali, J.; Saxena, D.; Nanduri, S.; Sonti, R.; Dasgupta, A.; Chopra, S.; Yaddanapudi, V. M. Synthesis of 1,3-Diaryl Substituted Pyrazole-Based Imidazo[1,2-a]Pyridine Carboxamides and Evaluation of Their Antitubercular Activity. Bioorganic & Medicinal Chemistry 2025, 129, 118341. https://doi.org/10.1016/j.bmc.2025.118341
93. Dannarm, S. R.; Gottimukkula, B. R.; Dhalaram, C. S.; Reddy, G. N.; Sonti, R. Environmental Degradation of the Anticancer Drug Encorafenib: Evidence for Cyclisation through Aromatic Ring Flip under Photolytic Conditions. Microchemical Journal 2025, 214, 113885. https://doi.org/10.1016/j.microc.2025.113885
94. Dandekar, M. P.; Guin, S.; Sammeta, S.; Saha, C.; Bhalerao, H. A.; Sonti, R. Polyherbal Formulation Mitigates Age-Associated Cognitive Deficits in Rats. Journal of Ayurveda and Integrative Medicine 2025, 16, 101131. https://doi.org/10.1016/j.jaim.2025.101131
95. Gajula, S. N. R.; Munjal, V.; Talari, S.; Rahman, Z.; Dandekar, M. P.; Sonti, R. The Influence of a Rat Model of Depression and Gastric Ulcer on the Pharmacokinetics of Encorafenib. Biopharmaceutics & Drug Disposition 2025, 46, 67. https://doi.org/10.1002/bdd.70006
96. Sahoo, D. K.; Nayak, A.; Dannarm, S. R.; Jahnavi, A. S.; Dikundwar, A. G.; Sonti, R.; Gowd, K. H. Pyrimidine Derivative Mimicking the Locked Enol Form of Avobenzone Acts as a Photostable UVAII and UVB Filter. Journal of Photochemistry and Photobiology A: Chemistry 2025, 459, 116099. https://doi.org/10.1016/j.jphotochem.2024.116099
97. Maddipatla, S.; Bakchi, B.; Shinde, M. A.; Bonardi, A.; Raman, P. K.; Bhalerao, H. A.; Singampalli, A.; Nanduri, S.; Godugu, C.; Sonti, R.; Supuran, C. T. New 7-Hydroxycoumarin Acetamide Derivatives as Human Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, Biological Evaluation and Molecular Docking Studies. Archiv der Pharmazie 2025, 358, e2400482. https://doi.org/10.1002/ardp.202400482
98. Mukhopadhyay, N.; Sen, S.; Kumar, A.; Sandbhor, R.; Dikundwar, A. G.; Kaki, V. R. Understanding Molecular Mechanisms Behind the Anti-Inflammatory Effects of Machilus macrantha (Gulmavu) by Network Pharmacology and Molecular Modeling Approach. Journal of Computational Biophysics and Chemistry 2025, 24 (8), 985–1007.
99. Narukulla, D. K.; Kaki, V. R. Sustainable Synthesis of Melitracen HCl and Its Key Intermediate, 10,10-Dimethylanthrone: A Green Solvent-Driven and Economically Efficient Approach with Comprehensive Sustainability Analysis Using iGAL 2.0. Journal of the Indian Chemical Society 2025, 102, 102067. (IF 3.4)
100. Shaikh, A. S.; Kumar, A.; Makhal, P. N.; Ikhe, A. S.; Bhale, N.; Dikundwar, A. G.; Kaki, V. R. Selective C3 Functionalization of 4H-Pyrido[1,2-a]pyrimidin-4-Ones via Glyoxylic Acid: Tuning Products with Temperature and Solvents. Asian Journal of Organic Chemistry 2025, 14 (5), e202400790. (IF 2.7)
101. Narukulla, D. K.; Vattikonda, L.; Kaki, V. R. Towards Sustainable and Scalable Synthesis of Amitriptyline Hydrochloride, Minoxidil, and Pyrrolidinyl Diaminopyrimidine Oxide. Journal of the Indian Chemical Society 2025, 101805. (IF 3.4)
102. Narukulla, D. K.; Kumar, A.; Kaki, V. R. Sustainability at Scale: Implementing a Green Solvent Approach for Grignard Reactions in the Synthesis of Key Intermediates for Active Pharmaceutical Ingredients (APIs). Journal of the Indian Chemical Society 2025, 101807. (IF 3.4)
103. Chauhan, Y.; Kumawat, A.; Singh, A.; Shankaraiah, N.; Kaki, V. R. Unravelling the Potential of Small Molecule Tumor Necrosis Factor-α (TNF) Inhibitors: A Comprehensive Review. Bioorganic & Medicinal Chemistry 2025, 130, 118344.
104. Shaikh, A. S.; Chilvery, S.; Patil, S.; Mourya, A.; Kumar, A.; Sharma, A.; Ikhe, A. S.; ...; Kaki, V. R. Unveiling Tetrahydroberberine–1,3,4-Oxadiazole Hybrids as Potent Anticancer Agents and MMP-9 Inhibitors with Comprehensive Insights from In Silico, In Vitro, and Ex Vivo Permeation Studies. Bioorganic Chemistry 2025, 163, 108791. (IF 4.7)
105. Dandekar, M. P.; Tadas, M.; Satthi, S.; Jangli, A.; Shaikh, A. S.; Gajula, S. N. R.; Kaki, V. R.; Sonti, R. Oxyberberine Revokes Letrozole-Induced Polycystic Ovarian Syndrome and Depression-Like Behavior in Female Sprague-Dawley Rats. European Journal of Pharmacology 2025, 997, 177613.
106. Negi, A.; Gaddam, H.; Beg, U. J.; Kaki, V. R. Synthesis of Substituted α-Carboline Derivatives by Base-Mediated Annulation of Azaindoles with Alkylidene Malononitriles. Synlett 2025, 36 (10), 1430–1434.
107. Shaikh, A. S.; Rathod, M. S.; Vemula, D.; Makhal, P. N.; Bhandhari, V.; Kaki, V. R. Metal-Free Amidation and Selenoamidation of 2-Methylquinolines with Secondary Amines Using Selenium Dioxide, and Antibacterial Evaluation of the Products. Synlett 2025, 36 (16), 2637–2642.
108. Negi, A.; Gupta, A. A.; Kikon, C. E.; Guru, S. K.; Kaki, V. R. The Reactivity of Indole-[3,4-b]-azepin-1,5-dione for Halogenations and Synthesis of Alkylamine Substituted Indole-[3,4-b]-azepine Derivatives. Synthetic Communications 2025, 55 (2), 166–174.